Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies
The hydrogel materials are getting attention from the research due to their multidimensional usage in various fields. Chitosan is one of the most important hydrogels used in this regard. In this paper multifunctional binary graft copolymeric matrices of chitosan with monomer AA and various comonomer...
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MDPI AG
2022-04-01
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| Online Access: | https://www.mdpi.com/1424-8220/22/9/3454 |
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| author | Lalita Chopra Jasgurpreet Singh Chohan Shubham Sharma Mariusz Pelc Aleksandra Kawala-Sterniuk |
| author_facet | Lalita Chopra Jasgurpreet Singh Chohan Shubham Sharma Mariusz Pelc Aleksandra Kawala-Sterniuk |
| author_sort | Lalita Chopra |
| collection | DOAJ |
| description | The hydrogel materials are getting attention from the research due to their multidimensional usage in various fields. Chitosan is one of the most important hydrogels used in this regard. In this paper multifunctional binary graft copolymeric matrices of chitosan with monomer AA and various comonomers AAm and AN were prepared by performing free radical graft copolymerization in the presence of an initiator KPS. The binary grafting can be done at five different molar concentrations of binary comonomers at already optimized concentration of AA, KPS and other reaction conditions such as time, temperature, solvent amount, etc. Various optimum reaction conditions were investigated and presented in this work; the backbone as well as binary grafts Ch-graft-poly (AA-cop-AAm) and Ch-graft-poly (AA-cop-AN) were characterized via various physio-chemical techniques of analysis such as SEM analysis, Xray diffraction (XRD), TGA/DTA and FTIR. In the batch experiments, the binary grafts were investigated for the percent swelling with respect to pH (pH of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2.2</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>7.0</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>7.4</mn></mrow></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>9.4</mn></mrow></semantics></math></inline-formula>) and time (contact time 1 to 24 h). Uploading and controllable in vitro release of the drug DS (anti-inflammatory) was examined with reverence to gastrointestinal pH and time. The binary grafts showed significantly better-controlled drug diffusion than the unmodified backbone. The kinetic study revealed that the diffusion of the drug occurred by the non-Fickian way. In the case of separation technologies, experiments (batch tests) were executed for the toxic bivalent metal ions Fe (II) and Pb (II) sorption from the aqueous media with respect to the parameters such as interaction period, concentration of fed metal ions in solution, pH and temperature. The binary grafted matrices showed superior results compared to chitosan. The kinetics study revealed that the matrices show pseudo-second order adsorption. The graft copolymer Ch-graft-poly (AA-cop-AAm) provided superior results in sustainable drug release as well as metal ion uptake. The study explored the potential of chitosan-based materials in the industry as well in the biomedical field. The results proved these to be excellent materials with a lot of potential as adsorbents. |
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| spelling | doaj.art-b2f7880e436c463992f823d3cb8e57e52023-11-23T09:18:43ZengMDPI AGSensors1424-82202022-04-01229345410.3390/s22093454Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake StudiesLalita Chopra0Jasgurpreet Singh Chohan1Shubham Sharma2Mariusz Pelc3Aleksandra Kawala-Sterniuk4Environment Chemistry Laboratory, Department of Chemistry (UIS), Chandigarh University, Mohali 140413, IndiaMechanical Engineering Department, University Centre for Research and Development, Chandigarh University, Mohali 140413, IndiaMechanical Engineering Department, University Centre for Research and Development, Chandigarh University, Mohali 140413, IndiaFaculty of Electrical Engineering, Automatic Control and Informatics, Opole University of Technology, ul. Proszkowska 76, 45-758 Opole, PolandFaculty of Electrical Engineering, Automatic Control and Informatics, Opole University of Technology, ul. Proszkowska 76, 45-758 Opole, PolandThe hydrogel materials are getting attention from the research due to their multidimensional usage in various fields. Chitosan is one of the most important hydrogels used in this regard. In this paper multifunctional binary graft copolymeric matrices of chitosan with monomer AA and various comonomers AAm and AN were prepared by performing free radical graft copolymerization in the presence of an initiator KPS. The binary grafting can be done at five different molar concentrations of binary comonomers at already optimized concentration of AA, KPS and other reaction conditions such as time, temperature, solvent amount, etc. Various optimum reaction conditions were investigated and presented in this work; the backbone as well as binary grafts Ch-graft-poly (AA-cop-AAm) and Ch-graft-poly (AA-cop-AN) were characterized via various physio-chemical techniques of analysis such as SEM analysis, Xray diffraction (XRD), TGA/DTA and FTIR. In the batch experiments, the binary grafts were investigated for the percent swelling with respect to pH (pH of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2.2</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>7.0</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>7.4</mn></mrow></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>9.4</mn></mrow></semantics></math></inline-formula>) and time (contact time 1 to 24 h). Uploading and controllable in vitro release of the drug DS (anti-inflammatory) was examined with reverence to gastrointestinal pH and time. The binary grafts showed significantly better-controlled drug diffusion than the unmodified backbone. The kinetic study revealed that the diffusion of the drug occurred by the non-Fickian way. In the case of separation technologies, experiments (batch tests) were executed for the toxic bivalent metal ions Fe (II) and Pb (II) sorption from the aqueous media with respect to the parameters such as interaction period, concentration of fed metal ions in solution, pH and temperature. The binary grafted matrices showed superior results compared to chitosan. The kinetics study revealed that the matrices show pseudo-second order adsorption. The graft copolymer Ch-graft-poly (AA-cop-AAm) provided superior results in sustainable drug release as well as metal ion uptake. The study explored the potential of chitosan-based materials in the industry as well in the biomedical field. The results proved these to be excellent materials with a lot of potential as adsorbents.https://www.mdpi.com/1424-8220/22/9/3454binary graft copolymersbackbonephysico-chemical analysisnon-Fickian diffusionadsorption |
| spellingShingle | Lalita Chopra Jasgurpreet Singh Chohan Shubham Sharma Mariusz Pelc Aleksandra Kawala-Sterniuk Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies Sensors binary graft copolymers backbone physico-chemical analysis non-Fickian diffusion adsorption |
| title | Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies |
| title_full | Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies |
| title_fullStr | Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies |
| title_full_unstemmed | Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies |
| title_short | Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies |
| title_sort | multifunctional modified chitosan biopolymers for dual applications in biomedical and industrial field synthesis and evaluation of thermal chemical morphological structural in vitro drug release rate swelling and metal uptake studies |
| topic | binary graft copolymers backbone physico-chemical analysis non-Fickian diffusion adsorption |
| url | https://www.mdpi.com/1424-8220/22/9/3454 |
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