Comparison of the efficacy of artemether-lumefantrine vs. artesunate plus sulfadoxine-pyrimethamine in children with uncomplicated falciparum malaria
Background World Health Organization (WHO) has recommended that countries with drug resistant malaria problem use combination therapies, especially artemisinin-based combination therapy (ACT). However, there is limited information on the efficacy of ACT in North Sulawesi. Objective To compare the ef...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2010-04-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1216 |
| Summary: | Background World Health Organization (WHO) has recommended
that countries with drug resistant malaria problem use
combination therapies, especially artemisinin-based combination
therapy (ACT). However, there is limited information on the
efficacy of ACT in North Sulawesi.
Objective To compare the efficacy of artemether-lumefanttine and
artesunate plus sulfadoxine-pyrimethamine (SP).
Methods This was a randomized experimental study, conducted in
Prof. Dr. R. D. Kandou General Hospital, Manado from January
until July 2009. There were 42 patients aged less than 13 years
treated with artemether-lumefanttine and artesunate plus SP. Body
temperature, parasite and gametocyte count were recorded every
day until day 7 and follow-up reviews were done on day 14 and
28.
Results Fever clearance time showed a significant difference
between artemether-lumefanttine group (median 27 hours) and
artesunate plus SP group (median 18 hours), P<0.05). There was
no significant difference in parasite clearance time (P>0.05) and
game tocyte clearance time (P > 0. 05) . The 28 day cure rate were
100% in the two groups. No side effect was found.
Conclusion Both artemether-lumefanttine and artesunate plus SP
combination are effective and safe for the treatment of falciparum
malaria in children. |
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| ISSN: | 0030-9311 2338-476X |