Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications
Bone tissue engineering has been becoming a promising strategy for surgical bone repair, but the risk of infection during trauma repair remains a problematic health concern worldwide, especially for fracture and infection-caused bone defects. Conventional antibiotics fail to effectively prevent or t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1030162/full |
| _version_ | 1811229370452279296 |
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| author | Zhuowen Hao Renxin Chen Chen Chai Yi Wang Tianhong Chen Hanke Li Yingkun Hu Qinyu Feng Jingfeng Li |
| author_facet | Zhuowen Hao Renxin Chen Chen Chai Yi Wang Tianhong Chen Hanke Li Yingkun Hu Qinyu Feng Jingfeng Li |
| author_sort | Zhuowen Hao |
| collection | DOAJ |
| description | Bone tissue engineering has been becoming a promising strategy for surgical bone repair, but the risk of infection during trauma repair remains a problematic health concern worldwide, especially for fracture and infection-caused bone defects. Conventional antibiotics fail to effectively prevent or treat bone infections during bone defect repair because of drug-resistance and recurrence, so novel antibacterial agents with limited resistance are highly needed for bone tissue engineering. Antimicrobial peptides (AMPs) characterized by cationic, hydrophobic and amphipathic properties show great promise to be used as next-generation antibiotics which rarely induce resistance and show potent antibacterial efficacy. In this review, four common structures of AMPs (helix-based, sheet-based, coil-based and composite) and related modifications are presented to identify AMPs and design novel analogs. Then, potential effects of AMPs for bone infection during bone repair are explored, including bactericidal activity, anti-biofilm, immunomodulation and regenerative properties. Moreover, we present distinctive applications of AMPs for topical bone repair, which can be either used by delivery system (surface immobilization, nanoparticles and hydrogels) or used in gene therapy. Finally, future prospects and ongoing challenges are discussed. |
| first_indexed | 2024-04-12T10:13:51Z |
| format | Article |
| id | doaj.art-b2fa91ac9a5547ecb878301163c90f17 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T10:13:51Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-b2fa91ac9a5547ecb878301163c90f172022-12-22T03:37:15ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-10-011010.3389/fbioe.2022.10301621030162Antimicrobial peptides for bone tissue engineering: Diversity, effects and applicationsZhuowen Hao0Renxin Chen1Chen Chai2Yi Wang3Tianhong Chen4Hanke Li5Yingkun Hu6Qinyu Feng7Jingfeng Li8Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, ChinaEmergency Center, Hubei Clinical Research Center for Emergency and Resuscitation, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, ChinaBone tissue engineering has been becoming a promising strategy for surgical bone repair, but the risk of infection during trauma repair remains a problematic health concern worldwide, especially for fracture and infection-caused bone defects. Conventional antibiotics fail to effectively prevent or treat bone infections during bone defect repair because of drug-resistance and recurrence, so novel antibacterial agents with limited resistance are highly needed for bone tissue engineering. Antimicrobial peptides (AMPs) characterized by cationic, hydrophobic and amphipathic properties show great promise to be used as next-generation antibiotics which rarely induce resistance and show potent antibacterial efficacy. In this review, four common structures of AMPs (helix-based, sheet-based, coil-based and composite) and related modifications are presented to identify AMPs and design novel analogs. Then, potential effects of AMPs for bone infection during bone repair are explored, including bactericidal activity, anti-biofilm, immunomodulation and regenerative properties. Moreover, we present distinctive applications of AMPs for topical bone repair, which can be either used by delivery system (surface immobilization, nanoparticles and hydrogels) or used in gene therapy. Finally, future prospects and ongoing challenges are discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1030162/fullantimicrobial peptidesbone regenerationtopical applicationsdelivery systemgene therapy |
| spellingShingle | Zhuowen Hao Renxin Chen Chen Chai Yi Wang Tianhong Chen Hanke Li Yingkun Hu Qinyu Feng Jingfeng Li Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications Frontiers in Bioengineering and Biotechnology antimicrobial peptides bone regeneration topical applications delivery system gene therapy |
| title | Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications |
| title_full | Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications |
| title_fullStr | Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications |
| title_full_unstemmed | Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications |
| title_short | Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications |
| title_sort | antimicrobial peptides for bone tissue engineering diversity effects and applications |
| topic | antimicrobial peptides bone regeneration topical applications delivery system gene therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1030162/full |
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