Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapy
Angiostrongylus cantonensis, the causative agent of human eosinophilic meningitis and eosinophilic meningoencepalitis, has been reported to cause cognitive impairments in the host. To determine whether drug treatment improves the cognitive functions, BALB/c mice infected with 50 third-stage larvae w...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118222000585 |
| _version_ | 1811237646706409472 |
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| author | Kai-Yuan Jhan Chien-Ju Cheng Chih-Jen Chou Shih-Ming Jung Guan-Jhih Lai Kuang-Yao Chen Lian-Chen Wang |
| author_facet | Kai-Yuan Jhan Chien-Ju Cheng Chih-Jen Chou Shih-Ming Jung Guan-Jhih Lai Kuang-Yao Chen Lian-Chen Wang |
| author_sort | Kai-Yuan Jhan |
| collection | DOAJ |
| description | Angiostrongylus cantonensis, the causative agent of human eosinophilic meningitis and eosinophilic meningoencepalitis, has been reported to cause cognitive impairments in the host. To determine whether drug treatment improves the cognitive functions, BALB/c mice infected with 50 third-stage larvae were treated with albendazole, dexamethasone, or co-therapy since day 7 or 14 post-infection for one or two weeks. Abilities of spatial memory and learning of these animals were assessed with the Morris water maze.Our results showed that body weight was significant higher then infected group in the albendazole and combined therapy groups. Significantly lower worm recovery rates were found in mice treated with the same groups. The mice treated with dexamethasone since day 7 for 14 day had significant longer time in the remaining groups were found in forced swimming test. The animals treated with albendazole and combined therapy since day 7 for 14 days was demonstrated to have significantly shorter latencies to the platform in learning memory on day 3 and 4. Mice in these two groups were demonstrated to have significantly higher sores in spatial memory tests. These results indicate that treatment with albendazole or combined therapy may be more efficient in preventing brain damages and depression as well as preserving their capabilities in learning and memory. Therefore, administration of albendazole alone or combined with dexamethasone should have higher efficacies than dexamethasone alone in treatment of BALB/c mice infected with a heavy dose of 50 third-stage larvae of A. cantonensis. |
| first_indexed | 2024-04-12T12:26:45Z |
| format | Article |
| id | doaj.art-b2fc3fd8cf2d4585952397cb9e9a1af1 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-12T12:26:45Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-b2fc3fd8cf2d4585952397cb9e9a1af12022-12-22T03:33:08ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822022-10-01555935945Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapyKai-Yuan Jhan0Chien-Ju Cheng1Chih-Jen Chou2Shih-Ming Jung3Guan-Jhih Lai4Kuang-Yao Chen5Lian-Chen Wang6Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Pathology, Chang-Gung Memorial Hospital, Chang-Gung Children Hospital at Linkou and Chang-Gung University, Taoyuan 333, TaiwanDepartment of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Corresponding author. Fax: +886 3 2118385Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Department of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; Corresponding author. Department of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. Fax: +886 3 2118385Angiostrongylus cantonensis, the causative agent of human eosinophilic meningitis and eosinophilic meningoencepalitis, has been reported to cause cognitive impairments in the host. To determine whether drug treatment improves the cognitive functions, BALB/c mice infected with 50 third-stage larvae were treated with albendazole, dexamethasone, or co-therapy since day 7 or 14 post-infection for one or two weeks. Abilities of spatial memory and learning of these animals were assessed with the Morris water maze.Our results showed that body weight was significant higher then infected group in the albendazole and combined therapy groups. Significantly lower worm recovery rates were found in mice treated with the same groups. The mice treated with dexamethasone since day 7 for 14 day had significant longer time in the remaining groups were found in forced swimming test. The animals treated with albendazole and combined therapy since day 7 for 14 days was demonstrated to have significantly shorter latencies to the platform in learning memory on day 3 and 4. Mice in these two groups were demonstrated to have significantly higher sores in spatial memory tests. These results indicate that treatment with albendazole or combined therapy may be more efficient in preventing brain damages and depression as well as preserving their capabilities in learning and memory. Therefore, administration of albendazole alone or combined with dexamethasone should have higher efficacies than dexamethasone alone in treatment of BALB/c mice infected with a heavy dose of 50 third-stage larvae of A. cantonensis.http://www.sciencedirect.com/science/article/pii/S1684118222000585Angiostrongylus cantonensisMorris water maze testSpatial memory and learningAlbendazoleDexamethasoneCo-therapy |
| spellingShingle | Kai-Yuan Jhan Chien-Ju Cheng Chih-Jen Chou Shih-Ming Jung Guan-Jhih Lai Kuang-Yao Chen Lian-Chen Wang Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapy Journal of Microbiology, Immunology and Infection Angiostrongylus cantonensis Morris water maze test Spatial memory and learning Albendazole Dexamethasone Co-therapy |
| title | Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapy |
| title_full | Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapy |
| title_fullStr | Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapy |
| title_full_unstemmed | Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapy |
| title_short | Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapy |
| title_sort | improvements of cognitive functions in mice heavily infected by angiostrongylus cantonensis after treatment with albendazole dexamethasone or co therapy |
| topic | Angiostrongylus cantonensis Morris water maze test Spatial memory and learning Albendazole Dexamethasone Co-therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1684118222000585 |
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