THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT
Parathyroid carcinoma (PC) is a rare neoplasm with a prevalence of only 0.005 % of all malignancies, and less than 1 % among patients with primary hyperparathyroidism. The diagnosis can be challenging due to the rarity of the disease, similarity of clinical features to parathyroid adenoma, and lack...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2017-04-01
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| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/254 |
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| author | V. A. Gorbunova E. A. Pigarova L. Ya. Rozhinskaya I. A. Voronkova Yu. A. Krupinova G. S. Emel’yanova L. S. Kruglova S. V. Shiryaev M. B. Dolgushin M. E. Bilik E. A. Kobyakova D. V. Komov |
| author_facet | V. A. Gorbunova E. A. Pigarova L. Ya. Rozhinskaya I. A. Voronkova Yu. A. Krupinova G. S. Emel’yanova L. S. Kruglova S. V. Shiryaev M. B. Dolgushin M. E. Bilik E. A. Kobyakova D. V. Komov |
| author_sort | V. A. Gorbunova |
| collection | DOAJ |
| description | Parathyroid carcinoma (PC) is a rare neoplasm with a prevalence of only 0.005 % of all malignancies, and less than 1 % among patients with primary hyperparathyroidism. The diagnosis can be challenging due to the rarity of the disease, similarity of clinical features to parathyroid adenoma, and lack of reliable morphological signs of the tumor. For metastatic cancer of the parathyroid gland does not exist standard drug therapy due to the rare occurrence of this disease. Chemotherapy and radiotherapy failed to show any significant effect on the course of the disease. We report the case of a 27-year old woman with PC previously misdiagnosed as benign thyroid nodule and multiple lung metastases. After the immunohistochemical study and confirm of diagnosis PC the patient was treatment with multikinase inhibitor sorafenib successfully. |
| first_indexed | 2024-04-10T01:58:57Z |
| format | Article |
| id | doaj.art-b2fd305b5ebd4dea8aed2c9bc3b0ae32 |
| institution | Directory Open Access Journal |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| last_indexed | 2024-04-10T01:58:57Z |
| publishDate | 2017-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj.art-b2fd305b5ebd4dea8aed2c9bc3b0ae322023-03-13T08:43:19ZrusABV-pressОпухоли головы и шеи2222-14682411-46342017-04-0164677210.17650/2222-1468-2016-6-4-67-72239THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORTV. A. Gorbunova0E. A. Pigarova1L. Ya. Rozhinskaya2I. A. Voronkova3Yu. A. Krupinova4G. S. Emel’yanova5L. S. Kruglova6S. V. Shiryaev7M. B. Dolgushin8M. E. Bilik9E. A. Kobyakova10D. V. Komov11Российский онкологический научный центр имени Н.Н. БлохинаЭндокринологический научный центрЭндокринологический научный центрЭндокринологический научный центрЭндокринологический научный центрМосковский государственный медико-стоматологический университет имени А.И. ЕвдокимоваЦентральная государственная медицинская академияРоссийский онкологический научный центр имени Н.Н. БлохинаРоссийский онкологический научный центр имени Н.Н. БлохинаРоссийский онкологический научный центр имени Н.Н. БлохинаРоссийский онкологический научный центр имени Н.Н. БлохинаРоссийский онкологический научный центр имени Н.Н. БлохинаParathyroid carcinoma (PC) is a rare neoplasm with a prevalence of only 0.005 % of all malignancies, and less than 1 % among patients with primary hyperparathyroidism. The diagnosis can be challenging due to the rarity of the disease, similarity of clinical features to parathyroid adenoma, and lack of reliable morphological signs of the tumor. For metastatic cancer of the parathyroid gland does not exist standard drug therapy due to the rare occurrence of this disease. Chemotherapy and radiotherapy failed to show any significant effect on the course of the disease. We report the case of a 27-year old woman with PC previously misdiagnosed as benign thyroid nodule and multiple lung metastases. After the immunohistochemical study and confirm of diagnosis PC the patient was treatment with multikinase inhibitor sorafenib successfully.https://ogsh.abvpress.ru/jour/article/view/254рак паращитовидных железметастазы в легкиепервичный гиперпаратиреозгиперкальциемиямультитаргетные ингибиторысорафениб |
| spellingShingle | V. A. Gorbunova E. A. Pigarova L. Ya. Rozhinskaya I. A. Voronkova Yu. A. Krupinova G. S. Emel’yanova L. S. Kruglova S. V. Shiryaev M. B. Dolgushin M. E. Bilik E. A. Kobyakova D. V. Komov THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT Опухоли головы и шеи рак паращитовидных желез метастазы в легкие первичный гиперпаратиреоз гиперкальциемия мультитаргетные ингибиторы сорафениб |
| title | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_full | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_fullStr | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_full_unstemmed | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_short | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_sort | use of sorafenib nexavar in treatment of patient with disseminated parathyroid cancer a case report |
| topic | рак паращитовидных желез метастазы в легкие первичный гиперпаратиреоз гиперкальциемия мультитаргетные ингибиторы сорафениб |
| url | https://ogsh.abvpress.ru/jour/article/view/254 |
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