Neuromedin U: A Small Peptide in the Big World of Cancer
Neuromedin U (NMU), a neuropeptide isolated from porcine spinal cord and named because of its activity as a rat uterus smooth muscle contraction inducer, is emerging as a new player in the tumorigenesis and/or metastasis of many types of cancers. Expressed in a variety of tissues, NMU has been shown...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/9/1312 |
| _version_ | 1797764203456495616 |
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| author | Patrycja Przygodzka Kamila Soboska Ewelina Sochacka Joanna Boncela |
| author_facet | Patrycja Przygodzka Kamila Soboska Ewelina Sochacka Joanna Boncela |
| author_sort | Patrycja Przygodzka |
| collection | DOAJ |
| description | Neuromedin U (NMU), a neuropeptide isolated from porcine spinal cord and named because of its activity as a rat uterus smooth muscle contraction inducer, is emerging as a new player in the tumorigenesis and/or metastasis of many types of cancers. Expressed in a variety of tissues, NMU has been shown to possess many important activities in the central nervous system as well as on the periphery. Along with the main structural and functional features of NMU and its currently known receptors, we summarized a growing number of recently published data from different tissues and cells that associate NMU activity with cancer development and progression. We ask if, based on current reports, NMU can be included as a marker of these processes and/or considered as a therapeutic target. |
| first_indexed | 2024-03-12T19:53:15Z |
| format | Article |
| id | doaj.art-b2fd5be93038452b88fccc9dc3683d56 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:53:15Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b2fd5be93038452b88fccc9dc3683d562023-08-02T03:03:39ZengMDPI AGCancers2072-66942019-09-01119131210.3390/cancers11091312cancers11091312Neuromedin U: A Small Peptide in the Big World of CancerPatrycja Przygodzka0Kamila Soboska1Ewelina Sochacka2Joanna Boncela3Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa Str, 93-232 Lodz, PolandInstitute of Medical Biology, Polish Academy of Sciences, 106 Lodowa Str, 93-232 Lodz, PolandInstitute of Medical Biology, Polish Academy of Sciences, 106 Lodowa Str, 93-232 Lodz, PolandInstitute of Medical Biology, Polish Academy of Sciences, 106 Lodowa Str, 93-232 Lodz, PolandNeuromedin U (NMU), a neuropeptide isolated from porcine spinal cord and named because of its activity as a rat uterus smooth muscle contraction inducer, is emerging as a new player in the tumorigenesis and/or metastasis of many types of cancers. Expressed in a variety of tissues, NMU has been shown to possess many important activities in the central nervous system as well as on the periphery. Along with the main structural and functional features of NMU and its currently known receptors, we summarized a growing number of recently published data from different tissues and cells that associate NMU activity with cancer development and progression. We ask if, based on current reports, NMU can be included as a marker of these processes and/or considered as a therapeutic target.https://www.mdpi.com/2072-6694/11/9/1312Neuromedin UNMUGPCR receptorscancer |
| spellingShingle | Patrycja Przygodzka Kamila Soboska Ewelina Sochacka Joanna Boncela Neuromedin U: A Small Peptide in the Big World of Cancer Cancers Neuromedin U NMU GPCR receptors cancer |
| title | Neuromedin U: A Small Peptide in the Big World of Cancer |
| title_full | Neuromedin U: A Small Peptide in the Big World of Cancer |
| title_fullStr | Neuromedin U: A Small Peptide in the Big World of Cancer |
| title_full_unstemmed | Neuromedin U: A Small Peptide in the Big World of Cancer |
| title_short | Neuromedin U: A Small Peptide in the Big World of Cancer |
| title_sort | neuromedin u a small peptide in the big world of cancer |
| topic | Neuromedin U NMU GPCR receptors cancer |
| url | https://www.mdpi.com/2072-6694/11/9/1312 |
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