Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis
Abstract Background Our objective was to examine the relationships between proximal tibial trabecular (epiphyseal and metaphyseal) bone mineral density (BMD) and osteoarthritis (OA)-related pain in patients with severe knee OA. Methods The knee was scanned preoperatively using quantitative computed...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-017-1415-9 |
| _version_ | 1811273621906128896 |
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| author | Wadena D. Burnett Saija A. Kontulainen Christine E. McLennan Diane Hazel Carl Talmo David R. Wilson David J. Hunter James D. Johnston |
| author_facet | Wadena D. Burnett Saija A. Kontulainen Christine E. McLennan Diane Hazel Carl Talmo David R. Wilson David J. Hunter James D. Johnston |
| author_sort | Wadena D. Burnett |
| collection | DOAJ |
| description | Abstract Background Our objective was to examine the relationships between proximal tibial trabecular (epiphyseal and metaphyseal) bone mineral density (BMD) and osteoarthritis (OA)-related pain in patients with severe knee OA. Methods The knee was scanned preoperatively using quantitative computed tomography (QCT) in 42 patients undergoing knee arthroplasty. OA severity was classified using radiographic Kellgren-Lawrence scoring and pain was measured using the pain subsection of the Western Ontario and McMaster Universities Arthritis Index (WOMAC). We used three-dimensional image processing techniques to assess tibial epiphyseal trabecular BMD between the epiphyseal line and 7.5 mm from the subchondral surface and tibial metaphyseal trabecular BMD 10 mm distal from the epiphyseal line. Regional analysis included the total epiphyseal and metaphyseal region, and the medial and lateral epiphyseal compartments. The association between total WOMAC pain scores and BMD measurements was assessed using hierarchical multiple regression with age, sex, and body mass index (BMI) as covariates. Statistical significance was set at p < 0.05. Results Total WOMAC pain was associated with total epiphyseal BMD adjusted for age, sex, and BMI (p = 0.013) and total metaphyseal BMD (p = 0.017). Regionally, total WOMAC pain was associated with medial epiphyseal BMD adjusted for age, sex, and BMI (p = 0.006). Conclusion These findings suggest that low proximal tibial trabecular BMD may have a role in OA-related pain pathogenesis. |
| first_indexed | 2024-04-12T23:02:44Z |
| format | Article |
| id | doaj.art-b2fde538b70e49ba9486b0efda0cce9c |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-12T23:02:44Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-b2fde538b70e49ba9486b0efda0cce9c2022-12-22T03:13:00ZengBMCArthritis Research & Therapy1478-63622017-09-011911910.1186/s13075-017-1415-9Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritisWadena D. Burnett0Saija A. Kontulainen1Christine E. McLennan2Diane Hazel3Carl Talmo4David R. Wilson5David J. Hunter6James D. Johnston7University of SaskatchewanUniversity of SaskatchewanNew England Baptist HospitalNew England Baptist HospitalNew England Baptist HospitalUniversity of British ColumbiaUniversity of SydneyUniversity of SaskatchewanAbstract Background Our objective was to examine the relationships between proximal tibial trabecular (epiphyseal and metaphyseal) bone mineral density (BMD) and osteoarthritis (OA)-related pain in patients with severe knee OA. Methods The knee was scanned preoperatively using quantitative computed tomography (QCT) in 42 patients undergoing knee arthroplasty. OA severity was classified using radiographic Kellgren-Lawrence scoring and pain was measured using the pain subsection of the Western Ontario and McMaster Universities Arthritis Index (WOMAC). We used three-dimensional image processing techniques to assess tibial epiphyseal trabecular BMD between the epiphyseal line and 7.5 mm from the subchondral surface and tibial metaphyseal trabecular BMD 10 mm distal from the epiphyseal line. Regional analysis included the total epiphyseal and metaphyseal region, and the medial and lateral epiphyseal compartments. The association between total WOMAC pain scores and BMD measurements was assessed using hierarchical multiple regression with age, sex, and body mass index (BMI) as covariates. Statistical significance was set at p < 0.05. Results Total WOMAC pain was associated with total epiphyseal BMD adjusted for age, sex, and BMI (p = 0.013) and total metaphyseal BMD (p = 0.017). Regionally, total WOMAC pain was associated with medial epiphyseal BMD adjusted for age, sex, and BMI (p = 0.006). Conclusion These findings suggest that low proximal tibial trabecular BMD may have a role in OA-related pain pathogenesis.http://link.springer.com/article/10.1186/s13075-017-1415-9OsteoarthritisBone mineral densityTibiaPainComputed tomography |
| spellingShingle | Wadena D. Burnett Saija A. Kontulainen Christine E. McLennan Diane Hazel Carl Talmo David R. Wilson David J. Hunter James D. Johnston Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis Arthritis Research & Therapy Osteoarthritis Bone mineral density Tibia Pain Computed tomography |
| title | Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis |
| title_full | Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis |
| title_fullStr | Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis |
| title_full_unstemmed | Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis |
| title_short | Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis |
| title_sort | proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis |
| topic | Osteoarthritis Bone mineral density Tibia Pain Computed tomography |
| url | http://link.springer.com/article/10.1186/s13075-017-1415-9 |
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