The genetic basis and fitness consequences of sperm midpiece size in deer mice
Across species there are large changes in sperm morphology, yet how and why is unclear. Here, the authors show in Peromyscus mice, that the sperm midpiece length influences swimming speed and male fertility, and is regulated by cell-type specific expression of a ubiquitously expressed gene, Prkar1a.
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13652 |
| _version_ | 1818834943016435712 |
|---|---|
| author | Heidi S. Fisher Emily Jacobs-Palmer Jean-Marc Lassance Hopi E. Hoekstra |
| author_facet | Heidi S. Fisher Emily Jacobs-Palmer Jean-Marc Lassance Hopi E. Hoekstra |
| author_sort | Heidi S. Fisher |
| collection | DOAJ |
| description | Across species there are large changes in sperm morphology, yet how and why is unclear. Here, the authors show in Peromyscus mice, that the sperm midpiece length influences swimming speed and male fertility, and is regulated by cell-type specific expression of a ubiquitously expressed gene, Prkar1a. |
| first_indexed | 2024-12-19T02:42:50Z |
| format | Article |
| id | doaj.art-b3015968c2c941efb2be5a5e4462c207 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:42:50Z |
| publishDate | 2016-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b3015968c2c941efb2be5a5e4462c2072022-12-21T20:39:04ZengNature PortfolioNature Communications2041-17232016-12-01711910.1038/ncomms13652The genetic basis and fitness consequences of sperm midpiece size in deer miceHeidi S. Fisher0Emily Jacobs-Palmer1Jean-Marc Lassance2Hopi E. Hoekstra3Department of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Museum of Comparative Zoology, Howard Hughes Medical Institute, Harvard UniversityDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Museum of Comparative Zoology, Howard Hughes Medical Institute, Harvard UniversityDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Museum of Comparative Zoology, Howard Hughes Medical Institute, Harvard UniversityDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Museum of Comparative Zoology, Howard Hughes Medical Institute, Harvard UniversityAcross species there are large changes in sperm morphology, yet how and why is unclear. Here, the authors show in Peromyscus mice, that the sperm midpiece length influences swimming speed and male fertility, and is regulated by cell-type specific expression of a ubiquitously expressed gene, Prkar1a.https://doi.org/10.1038/ncomms13652 |
| spellingShingle | Heidi S. Fisher Emily Jacobs-Palmer Jean-Marc Lassance Hopi E. Hoekstra The genetic basis and fitness consequences of sperm midpiece size in deer mice Nature Communications |
| title | The genetic basis and fitness consequences of sperm midpiece size in deer mice |
| title_full | The genetic basis and fitness consequences of sperm midpiece size in deer mice |
| title_fullStr | The genetic basis and fitness consequences of sperm midpiece size in deer mice |
| title_full_unstemmed | The genetic basis and fitness consequences of sperm midpiece size in deer mice |
| title_short | The genetic basis and fitness consequences of sperm midpiece size in deer mice |
| title_sort | genetic basis and fitness consequences of sperm midpiece size in deer mice |
| url | https://doi.org/10.1038/ncomms13652 |
| work_keys_str_mv | AT heidisfisher thegeneticbasisandfitnessconsequencesofspermmidpiecesizeindeermice AT emilyjacobspalmer thegeneticbasisandfitnessconsequencesofspermmidpiecesizeindeermice AT jeanmarclassance thegeneticbasisandfitnessconsequencesofspermmidpiecesizeindeermice AT hopiehoekstra thegeneticbasisandfitnessconsequencesofspermmidpiecesizeindeermice AT heidisfisher geneticbasisandfitnessconsequencesofspermmidpiecesizeindeermice AT emilyjacobspalmer geneticbasisandfitnessconsequencesofspermmidpiecesizeindeermice AT jeanmarclassance geneticbasisandfitnessconsequencesofspermmidpiecesizeindeermice AT hopiehoekstra geneticbasisandfitnessconsequencesofspermmidpiecesizeindeermice |