The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on
Faces play a crucial role in social interactions. Developmental prosopagnosia (DP) refers to the lifelong difficulty in recognizing faces despite the absence of obvious signs of brain lesions. In recent decades, the neural substrate of this condition has been extensively investigated. While early ne...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/10/1399 |
| _version_ | 1827721534552145920 |
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| author | Valerio Manippa Annalisa Palmisano Martina Ventura Davide Rivolta |
| author_facet | Valerio Manippa Annalisa Palmisano Martina Ventura Davide Rivolta |
| author_sort | Valerio Manippa |
| collection | DOAJ |
| description | Faces play a crucial role in social interactions. Developmental prosopagnosia (DP) refers to the lifelong difficulty in recognizing faces despite the absence of obvious signs of brain lesions. In recent decades, the neural substrate of this condition has been extensively investigated. While early neuroimaging studies did not reveal significant functional and structural abnormalities in the brains of individuals with developmental prosopagnosia (DPs), recent evidence identifies abnormalities at multiple levels within DPs’ face-processing networks. The current work aims to provide an overview of the convergent and contrasting findings by examining twenty-five years of neuroimaging literature on the anatomo-functional correlates of DP. We included 55 original papers, including 63 studies that compared the brain structure (MRI) and activity (fMRI, EEG, MEG) of healthy control participants and DPs. Despite variations in methods, procedures, outcomes, sample selection, and study design, this scoping review suggests that morphological, functional, and electrophysiological features characterize DPs’ brains, primarily within the ventral visual stream. Particularly, the functional and anatomical connectivity between the Fusiform Face Area and the other face-sensitive regions seems strongly impaired. The cognitive and clinical implications as well as the limitations of these findings are discussed in light of the available knowledge and challenges in the context of DP. |
| first_indexed | 2024-03-10T21:23:46Z |
| format | Article |
| id | doaj.art-b301c9453cb646309a23acc605035bf9 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T21:23:46Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-b301c9453cb646309a23acc605035bf92023-11-19T15:52:24ZengMDPI AGBrain Sciences2076-34252023-09-011310139910.3390/brainsci13101399The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years onValerio Manippa0Annalisa Palmisano1Martina Ventura2Davide Rivolta3Department of Education, Psychology and Communication, University of Bari Aldo Moro, 70122 Bari, ItalyDepartment of Education, Psychology and Communication, University of Bari Aldo Moro, 70122 Bari, ItalyDepartment of Education, Psychology and Communication, University of Bari Aldo Moro, 70122 Bari, ItalyDepartment of Education, Psychology and Communication, University of Bari Aldo Moro, 70122 Bari, ItalyFaces play a crucial role in social interactions. Developmental prosopagnosia (DP) refers to the lifelong difficulty in recognizing faces despite the absence of obvious signs of brain lesions. In recent decades, the neural substrate of this condition has been extensively investigated. While early neuroimaging studies did not reveal significant functional and structural abnormalities in the brains of individuals with developmental prosopagnosia (DPs), recent evidence identifies abnormalities at multiple levels within DPs’ face-processing networks. The current work aims to provide an overview of the convergent and contrasting findings by examining twenty-five years of neuroimaging literature on the anatomo-functional correlates of DP. We included 55 original papers, including 63 studies that compared the brain structure (MRI) and activity (fMRI, EEG, MEG) of healthy control participants and DPs. Despite variations in methods, procedures, outcomes, sample selection, and study design, this scoping review suggests that morphological, functional, and electrophysiological features characterize DPs’ brains, primarily within the ventral visual stream. Particularly, the functional and anatomical connectivity between the Fusiform Face Area and the other face-sensitive regions seems strongly impaired. The cognitive and clinical implications as well as the limitations of these findings are discussed in light of the available knowledge and challenges in the context of DP.https://www.mdpi.com/2076-3425/13/10/1399congenital prosopagnosiaface processingbrainneuroimaging |
| spellingShingle | Valerio Manippa Annalisa Palmisano Martina Ventura Davide Rivolta The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on Brain Sciences congenital prosopagnosia face processing brain neuroimaging |
| title | The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on |
| title_full | The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on |
| title_fullStr | The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on |
| title_full_unstemmed | The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on |
| title_short | The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on |
| title_sort | neural correlates of developmental prosopagnosia twenty five years on |
| topic | congenital prosopagnosia face processing brain neuroimaging |
| url | https://www.mdpi.com/2076-3425/13/10/1399 |
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