Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University
INTRODUCTION[|]Liver transplantation from deceased donors with a central nervous system (CNS) malignancy has some risk of tumor transmission to the recipient. Though the risk is small, this group of donors is regarded as marginal. The use of marginal grafts may be an acceptable alternative practice...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2017-11-01
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| Series: | İstanbul Kuzey Klinikleri |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-74436 |
| _version_ | 1797917955151888384 |
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| author | Volkan Ince Veysel Ersan Fatih Ozdemir Bora Barut Cemalettin Koc Burak Isik Cuneyt Kayaalp Sezai Yilmaz |
| author_facet | Volkan Ince Veysel Ersan Fatih Ozdemir Bora Barut Cemalettin Koc Burak Isik Cuneyt Kayaalp Sezai Yilmaz |
| author_sort | Volkan Ince |
| collection | DOAJ |
| description | INTRODUCTION[|]Liver transplantation from deceased donors with a central nervous system (CNS) malignancy has some risk of tumor transmission to the recipient. Though the risk is small, this group of donors is regarded as marginal. The use of marginal grafts may be an acceptable alternative practice in order to expand the donor pool in countries where there is a shortage of donated organs. The aim of this study was to examine and present the outcomes of liver transplantations performed using donors with a CNS tumor.[¤]METHODS[|]Between March 2002 and July 2017, 1990 (deceased donor: n=399, 20%; living donor: n=1591, 80%) liver transplantations were performed at the center. Of the 399 deceased donors, 17 (4.2%) had a CNS tumor. The data of donors with a CNS tumor and of recipients who survived for more than 1 month (n=11) were retrospectively reviewed. Demographic data, the grade of the CNS tumor, tumor transmission to recipient data, and survival rates were analyzed.[¤]RESULTS[|]Only 2 (18%) grafts were provided locally, 6 (54%) were offered to the transplantation center after all of the national centers had declined them, and 3 (37%) were made available to us by the national coordination center for patients with a documented notification of urgency. High-grade (grade III-IV) brain tumors were detected in 7 (64%) donors, while low-grade (grade I-II) tumors were found in 2 patients. The remaining 2 donors were not pathologically graded because the diagnosis was made radiologically. The 1-, 3-, and 5-year overall and tumor-free survival of the patients was estimated at 100%, 70%, and 45%, respectively.[¤]DISCUSSION AND CONCLUSION[|]A median survival of 40 months (range: 13-62 months) was achieved in recipients of grafts from a donor with a CNS tumor and no donor-related malignant transformation was observed.[¤] |
| first_indexed | 2024-04-10T13:22:50Z |
| format | Article |
| id | doaj.art-b3023b6c54224254b15504439fb262a7 |
| institution | Directory Open Access Journal |
| issn | 2148-4902 |
| language | English |
| last_indexed | 2024-04-10T13:22:50Z |
| publishDate | 2017-11-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | İstanbul Kuzey Klinikleri |
| spelling | doaj.art-b3023b6c54224254b15504439fb262a72023-02-15T16:12:00ZengKARE Publishingİstanbul Kuzey Klinikleri2148-49022017-11-014321321710.14744/nci.2017.74436NCI-74436Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu UniversityVolkan Ince0Veysel Ersan1Fatih Ozdemir2Bora Barut3Cemalettin Koc4Burak Isik5Cuneyt Kayaalp6Sezai Yilmaz7Department of General Surgery, Inonu University, Liver Transplantation Institute, Malatya, TurkeyDepartment of General Surgery, Inonu University, Liver Transplantation Institute, Malatya, TurkeyDepartment of General Surgery, Inonu University, Liver Transplantation Institute, Malatya, TurkeyDepartment of General Surgery, Inonu University, Liver Transplantation Institute, Malatya, TurkeyDepartment of General Surgery, Inonu University, Liver Transplantation Institute, Malatya, TurkeyDepartment of General Surgery, Inonu University, Liver Transplantation Institute, Malatya, TurkeyDepartment of General Surgery, Inonu University, Liver Transplantation Institute, Malatya, TurkeyDepartment of General Surgery, Inonu University, Liver Transplantation Institute, Malatya, TurkeyINTRODUCTION[|]Liver transplantation from deceased donors with a central nervous system (CNS) malignancy has some risk of tumor transmission to the recipient. Though the risk is small, this group of donors is regarded as marginal. The use of marginal grafts may be an acceptable alternative practice in order to expand the donor pool in countries where there is a shortage of donated organs. The aim of this study was to examine and present the outcomes of liver transplantations performed using donors with a CNS tumor.[¤]METHODS[|]Between March 2002 and July 2017, 1990 (deceased donor: n=399, 20%; living donor: n=1591, 80%) liver transplantations were performed at the center. Of the 399 deceased donors, 17 (4.2%) had a CNS tumor. The data of donors with a CNS tumor and of recipients who survived for more than 1 month (n=11) were retrospectively reviewed. Demographic data, the grade of the CNS tumor, tumor transmission to recipient data, and survival rates were analyzed.[¤]RESULTS[|]Only 2 (18%) grafts were provided locally, 6 (54%) were offered to the transplantation center after all of the national centers had declined them, and 3 (37%) were made available to us by the national coordination center for patients with a documented notification of urgency. High-grade (grade III-IV) brain tumors were detected in 7 (64%) donors, while low-grade (grade I-II) tumors were found in 2 patients. The remaining 2 donors were not pathologically graded because the diagnosis was made radiologically. The 1-, 3-, and 5-year overall and tumor-free survival of the patients was estimated at 100%, 70%, and 45%, respectively.[¤]DISCUSSION AND CONCLUSION[|]A median survival of 40 months (range: 13-62 months) was achieved in recipients of grafts from a donor with a CNS tumor and no donor-related malignant transformation was observed.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-74436central nervous system tumordeceasedliver transplantation. |
| spellingShingle | Volkan Ince Veysel Ersan Fatih Ozdemir Bora Barut Cemalettin Koc Burak Isik Cuneyt Kayaalp Sezai Yilmaz Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University İstanbul Kuzey Klinikleri central nervous system tumor deceased liver transplantation. |
| title | Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University |
| title_full | Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University |
| title_fullStr | Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University |
| title_full_unstemmed | Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University |
| title_short | Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University |
| title_sort | deceased donor liver transplantation from donors with central nervous system malignancy experience of the inonu university |
| topic | central nervous system tumor deceased liver transplantation. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-74436 |
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