Pathophysiology of Intestinal Na+/H+ ExchangeSummary
Several members of the SLC9A family of Na+/H+ exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of transepithelial Na+ absorption, intracellular pH (pHi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X16301229 |
| _version_ | 1811308645881741312 |
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| author | Michael A. Gurney Daniel Laubitz Fayez K. Ghishan Pawel R. Kiela |
| author_facet | Michael A. Gurney Daniel Laubitz Fayez K. Ghishan Pawel R. Kiela |
| author_sort | Michael A. Gurney |
| collection | DOAJ |
| description | Several members of the SLC9A family of Na+/H+ exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of transepithelial Na+ absorption, intracellular pH (pHi), cell volume, and nutrient absorption, but also in cellular proliferation, migration, and apoptosis. In addition, they modulate the extracellular milieu to facilitate other nutrient absorption and to regulate the intestinal microbial microenvironment. Na+/H+ exchangers are frequent targets of inhibition in gastrointestinal pathologies, either by intrinsic factors (eg, bile acids, inflammatory mediators) or infectious agents and associated microbial toxins. Based on emerging evidence, disruption of Na+/H+ exchange activity via impaired expression or function of respective isoforms may contribute not only to local and systemic electrolyte imbalance, but also to the disease severity via multiple mechanisms. Here, we review the current state of knowledge about the roles Na+/H+ exchangers play in the pathogenesis of disorders of diverse origin and affecting a range of gastrointestinal tissues. Keywords: Barrettâs Esophagus, Esophageal Adenocarcinoma, Epithelial Injury, Epithelial Restitution, Diarrhea, Infection, Inflammation, Microbiota, Inflammatory Bowel Disease, Hypertension |
| first_indexed | 2024-04-13T09:27:00Z |
| format | Article |
| id | doaj.art-b3027e16b81c4738b01d8159727bead2 |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-04-13T09:27:00Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-b3027e16b81c4738b01d8159727bead22022-12-22T02:52:24ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2017-01-01312740Pathophysiology of Intestinal Na+/H+ ExchangeSummaryMichael A. Gurney0Daniel Laubitz1Fayez K. Ghishan2Pawel R. Kiela3Department of Pediatrics, Steele Childrenâs Research Center, University of Arizona, Tucson, ArizonaDepartment of Pediatrics, Steele Childrenâs Research Center, University of Arizona, Tucson, ArizonaDepartment of Pediatrics, Steele Childrenâs Research Center, University of Arizona, Tucson, ArizonaDepartment of Pediatrics, Steele Childrenâs Research Center, University of Arizona, Tucson, Arizona; Department of Immunobiology, University of Arizona, Tucson, Arizona; Correspondence Address correspondence to: Pawel R. Kiela, DVM, PhD, Department of Pediatrics, University of Arizona, 1501 North Campbell Avenue, Tucson, Arizona 85724. fax: (520) 626-4141.Several members of the SLC9A family of Na+/H+ exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of transepithelial Na+ absorption, intracellular pH (pHi), cell volume, and nutrient absorption, but also in cellular proliferation, migration, and apoptosis. In addition, they modulate the extracellular milieu to facilitate other nutrient absorption and to regulate the intestinal microbial microenvironment. Na+/H+ exchangers are frequent targets of inhibition in gastrointestinal pathologies, either by intrinsic factors (eg, bile acids, inflammatory mediators) or infectious agents and associated microbial toxins. Based on emerging evidence, disruption of Na+/H+ exchange activity via impaired expression or function of respective isoforms may contribute not only to local and systemic electrolyte imbalance, but also to the disease severity via multiple mechanisms. Here, we review the current state of knowledge about the roles Na+/H+ exchangers play in the pathogenesis of disorders of diverse origin and affecting a range of gastrointestinal tissues. Keywords: Barrettâs Esophagus, Esophageal Adenocarcinoma, Epithelial Injury, Epithelial Restitution, Diarrhea, Infection, Inflammation, Microbiota, Inflammatory Bowel Disease, Hypertensionhttp://www.sciencedirect.com/science/article/pii/S2352345X16301229 |
| spellingShingle | Michael A. Gurney Daniel Laubitz Fayez K. Ghishan Pawel R. Kiela Pathophysiology of Intestinal Na+/H+ ExchangeSummary Cellular and Molecular Gastroenterology and Hepatology |
| title | Pathophysiology of Intestinal Na+/H+ ExchangeSummary |
| title_full | Pathophysiology of Intestinal Na+/H+ ExchangeSummary |
| title_fullStr | Pathophysiology of Intestinal Na+/H+ ExchangeSummary |
| title_full_unstemmed | Pathophysiology of Intestinal Na+/H+ ExchangeSummary |
| title_short | Pathophysiology of Intestinal Na+/H+ ExchangeSummary |
| title_sort | pathophysiology of intestinal na h exchangesummary |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X16301229 |
| work_keys_str_mv | AT michaelagurney pathophysiologyofintestinalnahexchangesummary AT daniellaubitz pathophysiologyofintestinalnahexchangesummary AT fayezkghishan pathophysiologyofintestinalnahexchangesummary AT pawelrkiela pathophysiologyofintestinalnahexchangesummary |