Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period
This descriptive prospective study investigated the clinical features and treatment adherence of individuals who started the treatment for Pulmonary tuberculosis (TB) during the COVID-19 pandemic in São Luís. Thirty-six TB patients and thirty-five age/sex-matched individuals were recruited between J...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/14/4843 |
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| author | Amanda Caroline de Souza Sales Larissa Araújo Lopes Maria Caroliny dos Santos Vale Mayara Ferreira Costa João Victor de Souza Lima João Gabriel Matos da Silva Bruna Sthefanny da Cunha Ferreira Victoria Alves do Nascimento Saara Emanuele da Silva Flor Elane Luiza Costa de Sousa Bruna Katarine Bezerra Paz Ricardo Amorim de Sousa Garcia Eduardo Martins de Sousa Alexsandro Ferreira dos Santos Luís Cláudio Nascimento da Silva Adrielle Zagmignan |
| author_facet | Amanda Caroline de Souza Sales Larissa Araújo Lopes Maria Caroliny dos Santos Vale Mayara Ferreira Costa João Victor de Souza Lima João Gabriel Matos da Silva Bruna Sthefanny da Cunha Ferreira Victoria Alves do Nascimento Saara Emanuele da Silva Flor Elane Luiza Costa de Sousa Bruna Katarine Bezerra Paz Ricardo Amorim de Sousa Garcia Eduardo Martins de Sousa Alexsandro Ferreira dos Santos Luís Cláudio Nascimento da Silva Adrielle Zagmignan |
| author_sort | Amanda Caroline de Souza Sales |
| collection | DOAJ |
| description | This descriptive prospective study investigated the clinical features and treatment adherence of individuals who started the treatment for Pulmonary tuberculosis (TB) during the COVID-19 pandemic in São Luís. Thirty-six TB patients and thirty-five age/sex-matched individuals were recruited between January 2021 and January 2022. The clinical features, sociodemographic information, and serum were obtained at the diagnosis time. Adherence to treatment and adverse reactions were investigated monthly. The most common symptoms in TB patients were cough (91.6%) and fever (83.3%). All TB patients had elevated pre-therapy levels of CRP and reduced HDL: 88.9% presented hypocalcemia and 47.2% showed elevated ALP and GGT. TB patients showed higher levels of ALT, AST, ALP, GGT, CRP, amylase, and triglycerides than the comparison group (<i>p</i> < 0.05), while the calcium levels were reduced (<i>p</i> < 0.0001). TB patients with anti-SARS-CoV-2-IgG antibodies (seroprevalence of 66.7%) presented higher values of amylase and lower CRP levels (<i>p</i> < 0.05). Most patients (~70%) reported at least one adverse drug reaction, mainly pruritus and nausea. The treatment abandonment rate was 19.2%. In conclusion, TB patients showed elevated pre-therapy levels of CRP, low levels of HDL, and hypocalcemia. Liver and pancreatic functions were also compromised in several patients before the therapy. The treatment non-adherence rate observed was similar to other studies performed before the pandemic period. |
| first_indexed | 2024-03-11T00:58:00Z |
| format | Article |
| id | doaj.art-b303c027bb204628b85b13caf3e52846 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:58:00Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b303c027bb204628b85b13caf3e528462023-11-18T19:54:49ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011214484310.3390/jcm12144843Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic PeriodAmanda Caroline de Souza Sales0Larissa Araújo Lopes1Maria Caroliny dos Santos Vale2Mayara Ferreira Costa3João Victor de Souza Lima4João Gabriel Matos da Silva5Bruna Sthefanny da Cunha Ferreira6Victoria Alves do Nascimento7Saara Emanuele da Silva Flor8Elane Luiza Costa de Sousa9Bruna Katarine Bezerra Paz10Ricardo Amorim de Sousa Garcia11Eduardo Martins de Sousa12Alexsandro Ferreira dos Santos13Luís Cláudio Nascimento da Silva14Adrielle Zagmignan15Laboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Clinical Analysis (LABORCEUMA), CEUMA University, São Luís 65075-120, MA, BrazilPostgraduate Program in Health and Services Management, CEUMA University, São Luís 65075-120, MA, BrazilPostgraduate Program in Microbial Biology, CEUMA University, São Luís 65075-120, MA, BrazilDepartament of Nutrition, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilLaboratory of Microbial Pathogenesis, CEUMA University, São Luís 65075-120, MA, BrazilThis descriptive prospective study investigated the clinical features and treatment adherence of individuals who started the treatment for Pulmonary tuberculosis (TB) during the COVID-19 pandemic in São Luís. Thirty-six TB patients and thirty-five age/sex-matched individuals were recruited between January 2021 and January 2022. The clinical features, sociodemographic information, and serum were obtained at the diagnosis time. Adherence to treatment and adverse reactions were investigated monthly. The most common symptoms in TB patients were cough (91.6%) and fever (83.3%). All TB patients had elevated pre-therapy levels of CRP and reduced HDL: 88.9% presented hypocalcemia and 47.2% showed elevated ALP and GGT. TB patients showed higher levels of ALT, AST, ALP, GGT, CRP, amylase, and triglycerides than the comparison group (<i>p</i> < 0.05), while the calcium levels were reduced (<i>p</i> < 0.0001). TB patients with anti-SARS-CoV-2-IgG antibodies (seroprevalence of 66.7%) presented higher values of amylase and lower CRP levels (<i>p</i> < 0.05). Most patients (~70%) reported at least one adverse drug reaction, mainly pruritus and nausea. The treatment abandonment rate was 19.2%. In conclusion, TB patients showed elevated pre-therapy levels of CRP, low levels of HDL, and hypocalcemia. Liver and pancreatic functions were also compromised in several patients before the therapy. The treatment non-adherence rate observed was similar to other studies performed before the pandemic period.https://www.mdpi.com/2077-0383/12/14/4843adverse drug reactionsbiochemical markersbacterial infections |
| spellingShingle | Amanda Caroline de Souza Sales Larissa Araújo Lopes Maria Caroliny dos Santos Vale Mayara Ferreira Costa João Victor de Souza Lima João Gabriel Matos da Silva Bruna Sthefanny da Cunha Ferreira Victoria Alves do Nascimento Saara Emanuele da Silva Flor Elane Luiza Costa de Sousa Bruna Katarine Bezerra Paz Ricardo Amorim de Sousa Garcia Eduardo Martins de Sousa Alexsandro Ferreira dos Santos Luís Cláudio Nascimento da Silva Adrielle Zagmignan Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period Journal of Clinical Medicine adverse drug reactions biochemical markers bacterial infections |
| title | Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period |
| title_full | Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period |
| title_fullStr | Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period |
| title_full_unstemmed | Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period |
| title_short | Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period |
| title_sort | clinical features biochemical parameters and treatment adherence of individuals who started the treatment for active pulmonary tuberculosis during the pandemic period |
| topic | adverse drug reactions biochemical markers bacterial infections |
| url | https://www.mdpi.com/2077-0383/12/14/4843 |
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