A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review
Abstract Background Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We her...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-05-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-018-0454-z |
| _version_ | 1823945565657890816 |
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| author | Tetsuro Kawazoe Hiroshi Saeki Keitaro Edahiro Shotaro Korehisa Daisuke Taniguchi Kensuke Kudou Ryota Nakanishi Nobuhide Kubo Koji Ando Yuichiro Nakashima Eiji Oki Minako Fujiwara Yoshinao Oda Yoshihiko Maehara |
| author_facet | Tetsuro Kawazoe Hiroshi Saeki Keitaro Edahiro Shotaro Korehisa Daisuke Taniguchi Kensuke Kudou Ryota Nakanishi Nobuhide Kubo Koji Ando Yuichiro Nakashima Eiji Oki Minako Fujiwara Yoshinao Oda Yoshihiko Maehara |
| author_sort | Tetsuro Kawazoe |
| collection | DOAJ |
| description | Abstract Background Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein provide the first case report of surgically resected MANEC arising in Barrett’s esophagus (BE). Case presentation A 70-year-old man presenting with abdominal pain was referred to our hospital. Upper endoscopy showed a type 0-IIa + IIc elevated lesion adjacent to BE. According to a biopsy specimen, the elevated lesion was diagnosed as adenocarcinoma with neuroendocrine differentiation. No lymphatic or distant metastasis was detected in the preoperative examination. Laparoscopic distal esophagectomy and proximal gastrectomy were performed, and a diagnosis of MANEC in BE was determined according to the surgically resected specimen. Conclusions A very rare case of MANEC in BE was detected. BE can be the origin of esophageal MANEC as well as adenocarcinoma. Due to the small number of esophageal or esophagogastric MANEC cases reported, further accumulation of such cases is necessary to recommend an optimal management strategy for esophageal or esophagogastric MANEC. |
| first_indexed | 2024-12-17T09:18:22Z |
| format | Article |
| id | doaj.art-b30808968e2a41f497396737559c1e5d |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-17T09:18:22Z |
| publishDate | 2018-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-b30808968e2a41f497396737559c1e5d2022-12-21T21:54:51ZengSpringerOpenSurgical Case Reports2198-77932018-05-01411610.1186/s40792-018-0454-zA case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and reviewTetsuro Kawazoe0Hiroshi Saeki1Keitaro Edahiro2Shotaro Korehisa3Daisuke Taniguchi4Kensuke Kudou5Ryota Nakanishi6Nobuhide Kubo7Koji Ando8Yuichiro Nakashima9Eiji Oki10Minako Fujiwara11Yoshinao Oda12Yoshihiko Maehara13Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityAbstract Background Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein provide the first case report of surgically resected MANEC arising in Barrett’s esophagus (BE). Case presentation A 70-year-old man presenting with abdominal pain was referred to our hospital. Upper endoscopy showed a type 0-IIa + IIc elevated lesion adjacent to BE. According to a biopsy specimen, the elevated lesion was diagnosed as adenocarcinoma with neuroendocrine differentiation. No lymphatic or distant metastasis was detected in the preoperative examination. Laparoscopic distal esophagectomy and proximal gastrectomy were performed, and a diagnosis of MANEC in BE was determined according to the surgically resected specimen. Conclusions A very rare case of MANEC in BE was detected. BE can be the origin of esophageal MANEC as well as adenocarcinoma. Due to the small number of esophageal or esophagogastric MANEC cases reported, further accumulation of such cases is necessary to recommend an optimal management strategy for esophageal or esophagogastric MANEC.http://link.springer.com/article/10.1186/s40792-018-0454-zMixed adenoneuroendocrine carcinoma (MANEC)Barrett’s esophagusNeuroendocrine tumor |
| spellingShingle | Tetsuro Kawazoe Hiroshi Saeki Keitaro Edahiro Shotaro Korehisa Daisuke Taniguchi Kensuke Kudou Ryota Nakanishi Nobuhide Kubo Koji Ando Yuichiro Nakashima Eiji Oki Minako Fujiwara Yoshinao Oda Yoshihiko Maehara A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review Surgical Case Reports Mixed adenoneuroendocrine carcinoma (MANEC) Barrett’s esophagus Neuroendocrine tumor |
| title | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
| title_full | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
| title_fullStr | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
| title_full_unstemmed | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
| title_short | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
| title_sort | case of mixed adenoneuroendocrine carcinoma manec arising in barrett s esophagus literature and review |
| topic | Mixed adenoneuroendocrine carcinoma (MANEC) Barrett’s esophagus Neuroendocrine tumor |
| url | http://link.springer.com/article/10.1186/s40792-018-0454-z |
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