Molecular determinants of large cargo transport into the nucleus

Molecular determinants of large cargo transport into the nucleus

Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact. For these cargoes, there is little quantitative underst...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Giulia Paci, Tiantian Zheng, Joana Caria, Anton Zilman, Edward A Lemke
Format: Artikel
Sprache:English
Veröffentlicht: eLife Sciences Publications Ltd 2020-07-01
Schriftenreihe:eLife
Schlagworte:
nuclear transport
permeabilized cells
large cargo
import kinetics
NLS
capsid
Online Zugang:https://elifesciences.org/articles/55963

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