Immune Modulation of Metastatic Niche Formation in the Bone
Bone metastasis is commonly seen in patients with breast cancer, prostate cancer and lung cancer. Tumor-intrinsic factors and the tumor microenvironment cooperate to affect the formation of bone metastatic niche. Within the bone microenvironment, immune cells have been regarded as a major contributo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.765994/full |
| _version_ | 1819259867919024128 |
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| author | Xinyu Cheng Zhan Wang Zhan Wang Zhan Wang |
| author_facet | Xinyu Cheng Zhan Wang Zhan Wang Zhan Wang |
| author_sort | Xinyu Cheng |
| collection | DOAJ |
| description | Bone metastasis is commonly seen in patients with breast cancer, prostate cancer and lung cancer. Tumor-intrinsic factors and the tumor microenvironment cooperate to affect the formation of bone metastatic niche. Within the bone microenvironment, immune cells have been regarded as a major contributor to metastatic progression. In this review, we describe the dynamic roles of immune cells in regulating metastatic homing, seeding, dormancy, and outgrowth in the bone. We also summarize the diverse functions of immune molecules including chemokines, cytokines, and exosomes in remodeling the bone metastatic niche. Furthermore, we discuss the therapeutic and prognostic potential of these cellular and molecular players in bone metastasis. |
| first_indexed | 2024-12-23T19:16:50Z |
| format | Article |
| id | doaj.art-b30ebb5753214f9e816b70dbf2707461 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T19:16:50Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b30ebb5753214f9e816b70dbf27074612022-12-21T17:34:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-10-011210.3389/fimmu.2021.765994765994Immune Modulation of Metastatic Niche Formation in the BoneXinyu Cheng0Zhan Wang1Zhan Wang2Zhan Wang3Department of Neonatology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaBone metastasis is commonly seen in patients with breast cancer, prostate cancer and lung cancer. Tumor-intrinsic factors and the tumor microenvironment cooperate to affect the formation of bone metastatic niche. Within the bone microenvironment, immune cells have been regarded as a major contributor to metastatic progression. In this review, we describe the dynamic roles of immune cells in regulating metastatic homing, seeding, dormancy, and outgrowth in the bone. We also summarize the diverse functions of immune molecules including chemokines, cytokines, and exosomes in remodeling the bone metastatic niche. Furthermore, we discuss the therapeutic and prognostic potential of these cellular and molecular players in bone metastasis.https://www.frontiersin.org/articles/10.3389/fimmu.2021.765994/fullbone metastasisdisseminated tumor cellsimmune cellschemokinescytokines |
| spellingShingle | Xinyu Cheng Zhan Wang Zhan Wang Zhan Wang Immune Modulation of Metastatic Niche Formation in the Bone Frontiers in Immunology bone metastasis disseminated tumor cells immune cells chemokines cytokines |
| title | Immune Modulation of Metastatic Niche Formation in the Bone |
| title_full | Immune Modulation of Metastatic Niche Formation in the Bone |
| title_fullStr | Immune Modulation of Metastatic Niche Formation in the Bone |
| title_full_unstemmed | Immune Modulation of Metastatic Niche Formation in the Bone |
| title_short | Immune Modulation of Metastatic Niche Formation in the Bone |
| title_sort | immune modulation of metastatic niche formation in the bone |
| topic | bone metastasis disseminated tumor cells immune cells chemokines cytokines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.765994/full |
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