Dendrimer-Coated Gold Nanoparticles for Efficient Folate-Targeted mRNA Delivery In Vitro

Dendrimer-Coated Gold Nanoparticles for Efficient Folate-Targeted mRNA Delivery In Vitro

Messenger RNA (mRNA) is not an attractive candidate for gene therapy due to its instability and has therefore received little attention. Recent studies show the advantage of mRNA over DNA, especially in cancer immunotherapy and vaccine development. This study aimed to formulate folic-acid-(FA)-modif...

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Bibliographic Details
Main Authors: Londiwe Simphiwe Mbatha, Fiona Maiyo, Aliscia Daniels, Moganavelli Singh
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
gold nanoparticles
PAMAM dendrimers
folic acid
mRNA
gene expression
Online Access:https://www.mdpi.com/1999-4923/13/6/900

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