HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
Abstract HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms an...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-023-01765-3 |
| _version_ | 1797854008130404352 |
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| author | Ganji Seeta Rama Raju Eluri Pavitra Sai Samyuktha Bandaru Ganji Lakshmi Varaprasad Ganji Purnachandra Nagaraju Rama Rao Malla Yun Suk Huh Young-Kyu Han |
| author_facet | Ganji Seeta Rama Raju Eluri Pavitra Sai Samyuktha Bandaru Ganji Lakshmi Varaprasad Ganji Purnachandra Nagaraju Rama Rao Malla Yun Suk Huh Young-Kyu Han |
| author_sort | Ganji Seeta Rama Raju |
| collection | DOAJ |
| description | Abstract HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications. |
| first_indexed | 2024-04-09T19:59:59Z |
| format | Article |
| id | doaj.art-b312d544bb98484e91fc02a03f64f3ae |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-04-09T19:59:59Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-b312d544bb98484e91fc02a03f64f3ae2023-04-03T05:18:48ZengBMCMolecular Cancer1476-45982023-03-0122111510.1186/s12943-023-01765-3HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancerGanji Seeta Rama Raju0Eluri Pavitra1Sai Samyuktha Bandaru2Ganji Lakshmi Varaprasad3Ganji Purnachandra Nagaraju4Rama Rao Malla5Yun Suk Huh6Young-Kyu Han7Department of Energy and Materials Engineering, Dongguk University–SeoulNanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha UniversityBaton Rouge General HospitalNanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha UniversitySchool of Medicine, Division of Hematology and Oncology, University of AlabamaCancer Biology Laboratory, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University)NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha UniversityDepartment of Energy and Materials Engineering, Dongguk University–SeoulAbstract HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.https://doi.org/10.1186/s12943-023-01765-3Breast cancerDrug resistanceHOTAIRMetastasisPrognosis |
| spellingShingle | Ganji Seeta Rama Raju Eluri Pavitra Sai Samyuktha Bandaru Ganji Lakshmi Varaprasad Ganji Purnachandra Nagaraju Rama Rao Malla Yun Suk Huh Young-Kyu Han HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer Molecular Cancer Breast cancer Drug resistance HOTAIR Metastasis Prognosis |
| title | HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer |
| title_full | HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer |
| title_fullStr | HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer |
| title_full_unstemmed | HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer |
| title_short | HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer |
| title_sort | hotair a potential metastatic drug resistant and prognostic regulator of breast cancer |
| topic | Breast cancer Drug resistance HOTAIR Metastasis Prognosis |
| url | https://doi.org/10.1186/s12943-023-01765-3 |
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