Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> Regeneration
The emergence and stabilization of a body axis is a major step in animal morphogenesis, determining the symmetry of the body plan as well as its polarity. To advance our understanding of the emergence of body axis polarity, we study regenerating <i>Hydra</i>. Axis polarity is strongly me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/2/360 |
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| author | Lital Shani-Zerbib Liora Garion Yonit Maroudas-Sacks Erez Braun Kinneret Keren |
| author_facet | Lital Shani-Zerbib Liora Garion Yonit Maroudas-Sacks Erez Braun Kinneret Keren |
| author_sort | Lital Shani-Zerbib |
| collection | DOAJ |
| description | The emergence and stabilization of a body axis is a major step in animal morphogenesis, determining the symmetry of the body plan as well as its polarity. To advance our understanding of the emergence of body axis polarity, we study regenerating <i>Hydra</i>. Axis polarity is strongly memorized in <i>Hydra</i> regeneration even in small tissue segments. What type of processes confer this memory? To gain insight into the emerging polarity, we utilize frustrating initial conditions by studying regenerating tissue strips which fold into hollow spheroids by adhering their distal ends of opposite original polarities. Despite the convoluted folding process and the tissue rearrangements during regeneration, these tissue strips develop in a reproducible manner, preserving the original polarity and yielding an ordered body plan. These observations suggest that the integration of mechanical and biochemical processes supported by their mutual feedback attracts the tissue dynamics towards a well-defined developmental trajectory biased by weak inherited cues from the parent animal. <i>Hydra</i> thus provide an example of dynamic canalization in which the dynamic rules are instilled, but, in contrast to the classical picture, the detailed developmental trajectory does not unfold in a programmatic manner. |
| first_indexed | 2024-03-09T21:52:08Z |
| format | Article |
| id | doaj.art-b31358fc034f42549b18f6cfed8c75ea |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T21:52:08Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-b31358fc034f42549b18f6cfed8c75ea2023-11-23T20:05:39ZengMDPI AGGenes2073-44252022-02-0113236010.3390/genes13020360Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> RegenerationLital Shani-Zerbib0Liora Garion1Yonit Maroudas-Sacks2Erez Braun3Kinneret Keren4Department of Physics, Technion—Israel Institute of Technology, Haifa 32000, IsraelDepartment of Physics, Technion—Israel Institute of Technology, Haifa 32000, IsraelDepartment of Physics, Technion—Israel Institute of Technology, Haifa 32000, IsraelDepartment of Physics, Technion—Israel Institute of Technology, Haifa 32000, IsraelDepartment of Physics, Technion—Israel Institute of Technology, Haifa 32000, IsraelThe emergence and stabilization of a body axis is a major step in animal morphogenesis, determining the symmetry of the body plan as well as its polarity. To advance our understanding of the emergence of body axis polarity, we study regenerating <i>Hydra</i>. Axis polarity is strongly memorized in <i>Hydra</i> regeneration even in small tissue segments. What type of processes confer this memory? To gain insight into the emerging polarity, we utilize frustrating initial conditions by studying regenerating tissue strips which fold into hollow spheroids by adhering their distal ends of opposite original polarities. Despite the convoluted folding process and the tissue rearrangements during regeneration, these tissue strips develop in a reproducible manner, preserving the original polarity and yielding an ordered body plan. These observations suggest that the integration of mechanical and biochemical processes supported by their mutual feedback attracts the tissue dynamics towards a well-defined developmental trajectory biased by weak inherited cues from the parent animal. <i>Hydra</i> thus provide an example of dynamic canalization in which the dynamic rules are instilled, but, in contrast to the classical picture, the detailed developmental trajectory does not unfold in a programmatic manner.https://www.mdpi.com/2073-4425/13/2/360<i>Hydra</i> regenerationbody axis polaritymorphogenesissupracellular actin fiberstopological defects |
| spellingShingle | Lital Shani-Zerbib Liora Garion Yonit Maroudas-Sacks Erez Braun Kinneret Keren Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> Regeneration Genes <i>Hydra</i> regeneration body axis polarity morphogenesis supracellular actin fibers topological defects |
| title | Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> Regeneration |
| title_full | Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> Regeneration |
| title_fullStr | Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> Regeneration |
| title_full_unstemmed | Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> Regeneration |
| title_short | Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> Regeneration |
| title_sort | canalized morphogenesis driven by inherited tissue asymmetries in i hydra i regeneration |
| topic | <i>Hydra</i> regeneration body axis polarity morphogenesis supracellular actin fibers topological defects |
| url | https://www.mdpi.com/2073-4425/13/2/360 |
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