Acute stroke in COVID-19 patients: A first year experience in a Colombian hospital
Background: COVID-19 may be a new risk factor for stroke. Stroke in COVID-19 varies from 1.1 to 8.1%. Various pathophysiological pathways predispose SARS-CoV-2 infected patients to stroke. Aim: To describe COVID-19 patients with acute stroke in one Colombian Center. Methods: From March 6 2020 and Ma...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Neurology Perspectives |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667049623000133 |
| _version_ | 1797797088034029568 |
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| author | N. Cerón Blanco C.A. Romero Hernández J. Vallejo Fernández |
| author_facet | N. Cerón Blanco C.A. Romero Hernández J. Vallejo Fernández |
| author_sort | N. Cerón Blanco |
| collection | DOAJ |
| description | Background: COVID-19 may be a new risk factor for stroke. Stroke in COVID-19 varies from 1.1 to 8.1%. Various pathophysiological pathways predispose SARS-CoV-2 infected patients to stroke. Aim: To describe COVID-19 patients with acute stroke in one Colombian Center. Methods: From March 6 2020 and March 6 2021 records of patients with acute stroke and in-hospital positive PCR (Polymerase Chain Reaction) test for Sars-CoV-2 infection were reviewed. Demographic, stroke and COVID-19 characteristics were extracted. Continuous variables were reported in means and ranges. Categorical variables were presented in frequencies and percentage. A descriptive narrative was performed. Results: Of 328 acute stroke patients 14 (4.2%) tested positive for PCR SARS-CoV-2. Mean age 56.4 years with 57% males. Five were (35.7%) without vascular risk factors but 9 (64.3%) overweight. Brain infarct diagnosed in 11 (78.5%), 53% with anterior circulation syndromes. Mean NIHSS score 11.8 and 7 (63%) received intravenous thrombolysis. Acute inflammatory blood biomarkers (D-dimer, ferritin, LDH elevated) were positive in all. 11 (78.5%) had symptomatic COVID-19 before stroke with a mean latency of 7 days. 12 (85.7%) had severe COVID-19 and 6 (42.8%) required mechanical ventilation. Outcome was unfavorable in 9 (64.3%) (The Modified Rankin Scale (mRS) >2), mean hospital stay was 21.8 days and in-hospital case fatality rate was 14.2%. Conclusion: In susceptible individuals COVID-19 predisposes to stroke. Hypercoagulation and immune thrombosis may be at the culprit for this state. In Colombia, COVID-19 patients with stroke have similar characteristics to the described worldwide. |
| first_indexed | 2024-03-13T03:43:52Z |
| format | Article |
| id | doaj.art-b3148046517e427c8b4b01785a8a23e4 |
| institution | Directory Open Access Journal |
| issn | 2667-0496 |
| language | English |
| last_indexed | 2024-03-13T03:43:52Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurology Perspectives |
| spelling | doaj.art-b3148046517e427c8b4b01785a8a23e42023-06-23T04:44:58ZengElsevierNeurology Perspectives2667-04962023-04-0132100121Acute stroke in COVID-19 patients: A first year experience in a Colombian hospitalN. Cerón Blanco0C.A. Romero Hernández1J. Vallejo Fernández2Residente de Neurología, Universidad del Rosario, Fundación, Cardioinfantil, Colombia; Corresponding author.Neurólogo vascular Fundación Cardioinfantil, Profesor de Neurología, Universidad del Rosario, Fundación, Cardioinfantil, ColombiaMédico Universidad del Rosario, ColombiaBackground: COVID-19 may be a new risk factor for stroke. Stroke in COVID-19 varies from 1.1 to 8.1%. Various pathophysiological pathways predispose SARS-CoV-2 infected patients to stroke. Aim: To describe COVID-19 patients with acute stroke in one Colombian Center. Methods: From March 6 2020 and March 6 2021 records of patients with acute stroke and in-hospital positive PCR (Polymerase Chain Reaction) test for Sars-CoV-2 infection were reviewed. Demographic, stroke and COVID-19 characteristics were extracted. Continuous variables were reported in means and ranges. Categorical variables were presented in frequencies and percentage. A descriptive narrative was performed. Results: Of 328 acute stroke patients 14 (4.2%) tested positive for PCR SARS-CoV-2. Mean age 56.4 years with 57% males. Five were (35.7%) without vascular risk factors but 9 (64.3%) overweight. Brain infarct diagnosed in 11 (78.5%), 53% with anterior circulation syndromes. Mean NIHSS score 11.8 and 7 (63%) received intravenous thrombolysis. Acute inflammatory blood biomarkers (D-dimer, ferritin, LDH elevated) were positive in all. 11 (78.5%) had symptomatic COVID-19 before stroke with a mean latency of 7 days. 12 (85.7%) had severe COVID-19 and 6 (42.8%) required mechanical ventilation. Outcome was unfavorable in 9 (64.3%) (The Modified Rankin Scale (mRS) >2), mean hospital stay was 21.8 days and in-hospital case fatality rate was 14.2%. Conclusion: In susceptible individuals COVID-19 predisposes to stroke. Hypercoagulation and immune thrombosis may be at the culprit for this state. In Colombia, COVID-19 patients with stroke have similar characteristics to the described worldwide.http://www.sciencedirect.com/science/article/pii/S2667049623000133StrokeSARS-CoV-2COVID-19TIAbrain infarct |
| spellingShingle | N. Cerón Blanco C.A. Romero Hernández J. Vallejo Fernández Acute stroke in COVID-19 patients: A first year experience in a Colombian hospital Neurology Perspectives Stroke SARS-CoV-2 COVID-19 TIA brain infarct |
| title | Acute stroke in COVID-19 patients: A first year experience in a Colombian hospital |
| title_full | Acute stroke in COVID-19 patients: A first year experience in a Colombian hospital |
| title_fullStr | Acute stroke in COVID-19 patients: A first year experience in a Colombian hospital |
| title_full_unstemmed | Acute stroke in COVID-19 patients: A first year experience in a Colombian hospital |
| title_short | Acute stroke in COVID-19 patients: A first year experience in a Colombian hospital |
| title_sort | acute stroke in covid 19 patients a first year experience in a colombian hospital |
| topic | Stroke SARS-CoV-2 COVID-19 TIA brain infarct |
| url | http://www.sciencedirect.com/science/article/pii/S2667049623000133 |
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