Hematological entities with plasmacytic differentiation: a case report
Abstract Introduction Plasmacytoma, a localized tumor of monoclonal plasma cells without any clinical, radiological or physical evidence of plasma cell neoplasm (PCN), is a rare entity that accounts for 1% of PCN. Immunoglobulin M (IgM) extramedullary plasmacytoma of mediastinal region has never bee...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-04082-x |
| _version_ | 1797559491439362048 |
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| author | Arati Inamdar Siddharth Bhattacharyya |
| author_facet | Arati Inamdar Siddharth Bhattacharyya |
| author_sort | Arati Inamdar |
| collection | DOAJ |
| description | Abstract Introduction Plasmacytoma, a localized tumor of monoclonal plasma cells without any clinical, radiological or physical evidence of plasma cell neoplasm (PCN), is a rare entity that accounts for 1% of PCN. Immunoglobulin M (IgM) extramedullary plasmacytoma of mediastinal region has never been reported and is a diagnostic challenge considering other differential diagnoses. Case presentation We present the case of a 51-year-old African-American female with progressively increasing cough, dyspnea, and dysphagia for 6 months with a computed tomography (CT) scan revealing a subcarinal mass. The histopathological analysis of the mass reveals a diagnosis of lymphoma with plasma cell differentiation, with a differential of lymphoplasmacytic lymphoma and plasma cell neoplasm. The lymphoma panel via next-generation sequencing (NGS) and a myeloma-targeted fluorescent in situ hybridization (FISH) panel confirmed the diagnosis of IgM extramedullary plasmacytoma, an entity of rare occurrence. Treatment with radiation led to complete regression of the plasmacytoma with normal blood work-up. Conclusions This report describes the challenges of diagnosing IgM extramedullary plasmactyoma. Our case report highlights the importance of cytogenetics and NGS in establishing a correct diagnosis that indeed has prognostic and therapeutic implications. |
| first_indexed | 2024-03-10T17:46:09Z |
| format | Article |
| id | doaj.art-b314f01e829a4b81876fa14da3f47373 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-10T17:46:09Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-b314f01e829a4b81876fa14da3f473732023-11-20T09:31:48ZengBMCJournal of Medical Case Reports1752-19472023-09-011711810.1186/s13256-023-04082-xHematological entities with plasmacytic differentiation: a case report Arati Inamdar0Siddharth Bhattacharyya1Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of PennsylvaniaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of PennsylvaniaAbstract Introduction Plasmacytoma, a localized tumor of monoclonal plasma cells without any clinical, radiological or physical evidence of plasma cell neoplasm (PCN), is a rare entity that accounts for 1% of PCN. Immunoglobulin M (IgM) extramedullary plasmacytoma of mediastinal region has never been reported and is a diagnostic challenge considering other differential diagnoses. Case presentation We present the case of a 51-year-old African-American female with progressively increasing cough, dyspnea, and dysphagia for 6 months with a computed tomography (CT) scan revealing a subcarinal mass. The histopathological analysis of the mass reveals a diagnosis of lymphoma with plasma cell differentiation, with a differential of lymphoplasmacytic lymphoma and plasma cell neoplasm. The lymphoma panel via next-generation sequencing (NGS) and a myeloma-targeted fluorescent in situ hybridization (FISH) panel confirmed the diagnosis of IgM extramedullary plasmacytoma, an entity of rare occurrence. Treatment with radiation led to complete regression of the plasmacytoma with normal blood work-up. Conclusions This report describes the challenges of diagnosing IgM extramedullary plasmactyoma. Our case report highlights the importance of cytogenetics and NGS in establishing a correct diagnosis that indeed has prognostic and therapeutic implications.https://doi.org/10.1186/s13256-023-04082-xCase reportImmunoglobulinsLymphomaNext generation sequencingPlasmacytoma |
| spellingShingle | Arati Inamdar Siddharth Bhattacharyya Hematological entities with plasmacytic differentiation: a case report Journal of Medical Case Reports Case report Immunoglobulins Lymphoma Next generation sequencing Plasmacytoma |
| title | Hematological entities with plasmacytic differentiation: a case report |
| title_full | Hematological entities with plasmacytic differentiation: a case report |
| title_fullStr | Hematological entities with plasmacytic differentiation: a case report |
| title_full_unstemmed | Hematological entities with plasmacytic differentiation: a case report |
| title_short | Hematological entities with plasmacytic differentiation: a case report |
| title_sort | hematological entities with plasmacytic differentiation a case report |
| topic | Case report Immunoglobulins Lymphoma Next generation sequencing Plasmacytoma |
| url | https://doi.org/10.1186/s13256-023-04082-x |
| work_keys_str_mv | AT aratiinamdar hematologicalentitieswithplasmacyticdifferentiationacasereport AT siddharthbhattacharyya hematologicalentitieswithplasmacyticdifferentiationacasereport |