Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders
Abstract Background Childhood maltreatment is an established risk factor for incident unipolar disorder and bipolar disorder. It is separately observed that affective disorders (AD) are also associated with higher nucleoside damage by oxidation. Childhood maltreatment may induce higher levels of n...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-01-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822023008/type/journal_article |
| _version_ | 1811156327501660160 |
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| author | Johanne Kofod Damm Eriksen Klara Coello Sharleny Stanislaus Hanne Lie Kjærstad Kimie Stefanie Ormstrup Sletved Roger S. McIntyre Maria Faurholt-Jepsen Kamilla K. Miskowiak Henrik Enghusen Poulsen Lars Vedel Kessing Maj Vinberg |
| author_facet | Johanne Kofod Damm Eriksen Klara Coello Sharleny Stanislaus Hanne Lie Kjærstad Kimie Stefanie Ormstrup Sletved Roger S. McIntyre Maria Faurholt-Jepsen Kamilla K. Miskowiak Henrik Enghusen Poulsen Lars Vedel Kessing Maj Vinberg |
| author_sort | Johanne Kofod Damm Eriksen |
| collection | DOAJ |
| description |
Abstract
Background
Childhood maltreatment is an established risk factor for incident unipolar disorder and bipolar disorder. It is separately observed that affective disorders (AD) are also associated with higher nucleoside damage by oxidation. Childhood maltreatment may induce higher levels of nucleoside damage by oxidation and thus contribute to the development of AD; however, this relation is only sparsely investigated.
Methods
In total, 860 participants (468 patients with AD, 151 unaffected first-degree relatives, and 241 healthy control persons) completed the Childhood Trauma Questionnaire (CTQ). The association between CTQ scores and markers of systemic DNA and RNA damage by oxidation as measured by urinary excretion of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) levels, respectively, was investigated.
Results
In multiple regression models adjusted for sex- and age, 8-oxodG and 8-oxoGuo levels were found to be higher in individuals who had experienced more childhood maltreatment. These associations persisted in models additionally adjusted for body mass index, alcohol, and current smoking status. Emotional abuse, sexual abuse, and emotional neglect were principally responsible for the foregoing associations.
Conclusions
Our findings of an association between childhood maltreatment and oxidative stress markers suggest that childhood maltreatment overall, notably emotional abuse and emotional neglect, is associated with enhanced systemic damage to DNA and RNA in adulthood. Further, individuals with AD reported a higher prevalence of childhood maltreatment, which may induce higher levels of nucleoside damage by oxidation in adulthood, possibly leading to increased risk of developing AD. Longitudinal studies are needed to clarify this relationship further.
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| first_indexed | 2024-04-10T04:49:38Z |
| format | Article |
| id | doaj.art-b317113564c04e178ebc787d42c628a1 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-04-10T04:49:38Z |
| publishDate | 2022-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-b317113564c04e178ebc787d42c628a12023-03-09T12:33:56ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-01-016510.1192/j.eurpsy.2022.2300Associations between childhood maltreatment and oxidative nucleoside damage in affective disordersJohanne Kofod Damm Eriksen0https://orcid.org/0000-0001-6647-0062Klara Coello1Sharleny Stanislaus2https://orcid.org/0000-0003-1073-6436Hanne Lie Kjærstad3https://orcid.org/0000-0001-7781-8853Kimie Stefanie Ormstrup Sletved4Roger S. McIntyre5Maria Faurholt-Jepsen6https://orcid.org/0000-0002-0462-6444Kamilla K. Miskowiak7Henrik Enghusen Poulsen8https://orcid.org/0000-0003-4242-9924Lars Vedel Kessing9https://orcid.org/0000-0001-9377-9436Maj Vinberg10https://orcid.org/0000-0002-5982-1335Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, Denmark Mental Health Centre, Northern Zealand, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, DenmarkCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, DenmarkCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, DenmarkCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, DenmarkCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, Denmark Department of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkMood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, CanadaCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, DenmarkCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Department of Endocrinology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark Department of Cardiology, Northern Zealand, Copenhagen University Hospital, Copenhagen, DenmarkCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, Denmark Department of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkCopenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, Denmark Mental Health Centre, Northern Zealand, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Abstract Background Childhood maltreatment is an established risk factor for incident unipolar disorder and bipolar disorder. It is separately observed that affective disorders (AD) are also associated with higher nucleoside damage by oxidation. Childhood maltreatment may induce higher levels of nucleoside damage by oxidation and thus contribute to the development of AD; however, this relation is only sparsely investigated. Methods In total, 860 participants (468 patients with AD, 151 unaffected first-degree relatives, and 241 healthy control persons) completed the Childhood Trauma Questionnaire (CTQ). The association between CTQ scores and markers of systemic DNA and RNA damage by oxidation as measured by urinary excretion of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) levels, respectively, was investigated. Results In multiple regression models adjusted for sex- and age, 8-oxodG and 8-oxoGuo levels were found to be higher in individuals who had experienced more childhood maltreatment. These associations persisted in models additionally adjusted for body mass index, alcohol, and current smoking status. Emotional abuse, sexual abuse, and emotional neglect were principally responsible for the foregoing associations. Conclusions Our findings of an association between childhood maltreatment and oxidative stress markers suggest that childhood maltreatment overall, notably emotional abuse and emotional neglect, is associated with enhanced systemic damage to DNA and RNA in adulthood. Further, individuals with AD reported a higher prevalence of childhood maltreatment, which may induce higher levels of nucleoside damage by oxidation in adulthood, possibly leading to increased risk of developing AD. Longitudinal studies are needed to clarify this relationship further. https://www.cambridge.org/core/product/identifier/S0924933822023008/type/journal_articleAffective disorderchildhood maltreatmentoxidative stressunaffected relatives |
| spellingShingle | Johanne Kofod Damm Eriksen Klara Coello Sharleny Stanislaus Hanne Lie Kjærstad Kimie Stefanie Ormstrup Sletved Roger S. McIntyre Maria Faurholt-Jepsen Kamilla K. Miskowiak Henrik Enghusen Poulsen Lars Vedel Kessing Maj Vinberg Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders European Psychiatry Affective disorder childhood maltreatment oxidative stress unaffected relatives |
| title | Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders |
| title_full | Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders |
| title_fullStr | Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders |
| title_full_unstemmed | Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders |
| title_short | Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders |
| title_sort | associations between childhood maltreatment and oxidative nucleoside damage in affective disorders |
| topic | Affective disorder childhood maltreatment oxidative stress unaffected relatives |
| url | https://www.cambridge.org/core/product/identifier/S0924933822023008/type/journal_article |
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