Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk
Background: Polycystic ovary syndrome (PCOS) is known as a metabolic disorder. The results of recent studies implied that vitamin D receptor (VDR) genetic variants may impact PCOS and insulin resistance in women with PCOS. The aim of the present study was to determine the VDR TaqI gene variant i...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2013-07-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | http://www.ijfs.ir/article_45180_d41d8cd98f00b204e9800998ecf8427e.pdf |
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| author | Morteza Bagheri Isa Abdi Rad Nima Hosseini Jazani Fariba Nanbakhsh |
| author_facet | Morteza Bagheri Isa Abdi Rad Nima Hosseini Jazani Fariba Nanbakhsh |
| author_sort | Morteza Bagheri |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome (PCOS) is known as a metabolic disorder. The results of recent studies implied that vitamin D receptor (VDR) genetic variants may impact PCOS and insulin resistance in women with PCOS. The aim of the present study was to determine the VDR TaqI gene variant in exon 9 (T/C) (rs731236) in normal controls and patients with PCOS for the first time in Iranian Azeri women. Materials and Methods: In this case control study between April 2011 and June 2012, a total of 76 women aged 18-40 years (38 patients with PCOS and 38 healthy women as normal controls) participated. Genotypes of VDR TaqI in exon 9 (T/C) (rs731236) were determined using the PCR-RFLP method. Results: The frequencies of VDR TaqI T anc C alleles were 0.605 and 0.395 in cases and 0.697 and 0.303 in controls. Also, the genotypic frequencies of VDR TaqI were 16) (42.11), 14(36.84), and 8(21.05) in cases, and 17(44.74), 19(50), and 2(5.26) in controls for TT, TC and CC genotypes respectively. There was no difference in genotype and allele frequencies between PCOS and controls (p value>0.05) with the exception of the CC genotype (p value=0.04). Conclusion: This report, a first of its own kind in Iranian Azeri patients, suggests that the CC genotype of VDR TaqI in exon 9 (rs731236) is associated with PCOS. |
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| format | Article |
| id | doaj.art-b317617efffe4aa4b9aad2e8ff3a8db0 |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-12T20:19:20Z |
| publishDate | 2013-07-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-b317617efffe4aa4b9aad2e8ff3a8db02022-12-22T00:13:18ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782013-07-017211612145180Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome RiskMorteza Bagheri0Isa Abdi Rad1Nima Hosseini Jazani2Fariba Nanbakhsh3Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran;Department of Genetics, Urmia University of Medical Sciences, Urmia, Iran;Cellular and Molecular Research Center, Urmia University of MedDepartment of Genetics, Urmia University of Medical Sciences, Urmia, Iran;Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, IranFood and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran;Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran4Reproductive Health Research Center, Department of Obstetrics and Gynecology, Urmia University of Medical Sciences, Urmia, IranBackground: Polycystic ovary syndrome (PCOS) is known as a metabolic disorder. The results of recent studies implied that vitamin D receptor (VDR) genetic variants may impact PCOS and insulin resistance in women with PCOS. The aim of the present study was to determine the VDR TaqI gene variant in exon 9 (T/C) (rs731236) in normal controls and patients with PCOS for the first time in Iranian Azeri women. Materials and Methods: In this case control study between April 2011 and June 2012, a total of 76 women aged 18-40 years (38 patients with PCOS and 38 healthy women as normal controls) participated. Genotypes of VDR TaqI in exon 9 (T/C) (rs731236) were determined using the PCR-RFLP method. Results: The frequencies of VDR TaqI T anc C alleles were 0.605 and 0.395 in cases and 0.697 and 0.303 in controls. Also, the genotypic frequencies of VDR TaqI were 16) (42.11), 14(36.84), and 8(21.05) in cases, and 17(44.74), 19(50), and 2(5.26) in controls for TT, TC and CC genotypes respectively. There was no difference in genotype and allele frequencies between PCOS and controls (p value>0.05) with the exception of the CC genotype (p value=0.04). Conclusion: This report, a first of its own kind in Iranian Azeri patients, suggests that the CC genotype of VDR TaqI in exon 9 (rs731236) is associated with PCOS.http://www.ijfs.ir/article_45180_d41d8cd98f00b204e9800998ecf8427e.pdfvitamin d receptorpolycystic ovary syndromegenetic variation |
| spellingShingle | Morteza Bagheri Isa Abdi Rad Nima Hosseini Jazani Fariba Nanbakhsh Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk International Journal of Fertility and Sterility vitamin d receptor polycystic ovary syndrome genetic variation |
| title | Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk |
| title_full | Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk |
| title_fullStr | Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk |
| title_full_unstemmed | Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk |
| title_short | Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk |
| title_sort | vitamin d receptor taqi gene variant in exon 9 and polycystic ovary syndrome risk |
| topic | vitamin d receptor polycystic ovary syndrome genetic variation |
| url | http://www.ijfs.ir/article_45180_d41d8cd98f00b204e9800998ecf8427e.pdf |
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