The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse

The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse

The aim of the present study was to further explore the in vivo function of the Leucine-rich repeat kinase 2 (LRRK2)-gene, which is mutated in certain familial forms of Parkinson's disease (PD). We generated a mouse model harboring the disease-associated point mutation R1441C in the GTPase doma...

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Bibliographic Details
Main Authors: F. Giesert, L. Glasl, A. Zimprich, L. Ernst, G. Piccoli, C. Stautner, J. Zerle, S.M. Hölter, D.M. Vogt Weisenhorn, W. Wurst
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Neurobiology of Disease
Subjects:
Genetic mouse model of Parkinson's disease
Behavioral phenotyping
Prodromal symptoms
Neurodegenertion
Knock-out–knock-in models
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301237

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http://www.sciencedirect.com/science/article/pii/S0969996117301237

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