Assessing left ventricular systolic function in children with a history of Kawasaki disease
Abstract Background The incidence of Kawasaki disease (KD) is increasing. Indeed, KD has become the most common cause of acquired heart disease in children. Previous studies have well summarized the acute phase left ventricular (LV) systolic dysfunction using speckle tracking echocardiography (STE);...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-020-01409-0 |
| _version_ | 1818890724518658048 |
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| author | Zhou Lin Jingjing Zheng Weiling Chen Tingting Ding Wei Yu Bei Xia |
| author_facet | Zhou Lin Jingjing Zheng Weiling Chen Tingting Ding Wei Yu Bei Xia |
| author_sort | Zhou Lin |
| collection | DOAJ |
| description | Abstract Background The incidence of Kawasaki disease (KD) is increasing. Indeed, KD has become the most common cause of acquired heart disease in children. Previous studies have well summarized the acute phase left ventricular (LV) systolic dysfunction using speckle tracking echocardiography (STE); however, changes in LV systolic function after long-term follow-up remain unclear. Methods One hundred children with a history of KD, but without coronary artery aneurysms, were enrolled. These children were divided into two subgroups based on the presence or absence of coronary artery dilatation (CAD). The duration of follow-up was > 7 years. The control group consisted of 51 healthy children. The LV myocardial strain were measured by two- and three-dimensional STE. Results Two-dimensional STE not only revealed that LV longitudinal strain decreased in part of segments in both KD groups, but also showed that global strain decreased in the KD group with CAD compared to the controls (P < 0.05). Global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were obtained by 3D STE. Compared to the controls, GLS and GAS decreased in both KD groups (P < 0.05). GCS and GRS decreased in the KD group with CAD, but was unchanged in the KD group without CAD (P < 0.05). Conclusions LV systolic dysfunction in children with KD and CAD was more severe than KD children without CAD compared to healthy children. This dysfunction can be assessed by LV regional and global myocardial strain using two- and three-dimensional STE. |
| first_indexed | 2024-12-19T17:29:28Z |
| format | Article |
| id | doaj.art-b3182729609540ad96bcd2a37278881c |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-19T17:29:28Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-b3182729609540ad96bcd2a37278881c2022-12-21T20:12:29ZengBMCBMC Cardiovascular Disorders1471-22612020-03-012011910.1186/s12872-020-01409-0Assessing left ventricular systolic function in children with a history of Kawasaki diseaseZhou Lin0Jingjing Zheng1Weiling Chen2Tingting Ding3Wei Yu4Bei Xia5Department of Ultrasound, Shenzhen Children’s HospitalDepartment of Ultrasound, Shenzhen Children’s HospitalDepartment of Ultrasound, Shenzhen Children’s HospitalDepartment of Ultrasound, Shenzhen Children’s HospitalDepartment of Ultrasound, Shenzhen Children’s HospitalDepartment of Ultrasound, Shenzhen Children’s HospitalAbstract Background The incidence of Kawasaki disease (KD) is increasing. Indeed, KD has become the most common cause of acquired heart disease in children. Previous studies have well summarized the acute phase left ventricular (LV) systolic dysfunction using speckle tracking echocardiography (STE); however, changes in LV systolic function after long-term follow-up remain unclear. Methods One hundred children with a history of KD, but without coronary artery aneurysms, were enrolled. These children were divided into two subgroups based on the presence or absence of coronary artery dilatation (CAD). The duration of follow-up was > 7 years. The control group consisted of 51 healthy children. The LV myocardial strain were measured by two- and three-dimensional STE. Results Two-dimensional STE not only revealed that LV longitudinal strain decreased in part of segments in both KD groups, but also showed that global strain decreased in the KD group with CAD compared to the controls (P < 0.05). Global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were obtained by 3D STE. Compared to the controls, GLS and GAS decreased in both KD groups (P < 0.05). GCS and GRS decreased in the KD group with CAD, but was unchanged in the KD group without CAD (P < 0.05). Conclusions LV systolic dysfunction in children with KD and CAD was more severe than KD children without CAD compared to healthy children. This dysfunction can be assessed by LV regional and global myocardial strain using two- and three-dimensional STE.http://link.springer.com/article/10.1186/s12872-020-01409-0Kawasaki diseaseSpeckle tacking echocardiographyLong-termFollow-up |
| spellingShingle | Zhou Lin Jingjing Zheng Weiling Chen Tingting Ding Wei Yu Bei Xia Assessing left ventricular systolic function in children with a history of Kawasaki disease BMC Cardiovascular Disorders Kawasaki disease Speckle tacking echocardiography Long-term Follow-up |
| title | Assessing left ventricular systolic function in children with a history of Kawasaki disease |
| title_full | Assessing left ventricular systolic function in children with a history of Kawasaki disease |
| title_fullStr | Assessing left ventricular systolic function in children with a history of Kawasaki disease |
| title_full_unstemmed | Assessing left ventricular systolic function in children with a history of Kawasaki disease |
| title_short | Assessing left ventricular systolic function in children with a history of Kawasaki disease |
| title_sort | assessing left ventricular systolic function in children with a history of kawasaki disease |
| topic | Kawasaki disease Speckle tacking echocardiography Long-term Follow-up |
| url | http://link.springer.com/article/10.1186/s12872-020-01409-0 |
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