Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1<i>H</i>-indoles and 5-(4-Methoxyphenyl)-1<i>H</i>-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?

Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1<i>H</i>-indoles and 5-(4-Methoxyphenyl)-1<i>H</i>-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?

Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research...

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Bibliographic Details
Main Authors: Alexander Zhuravlev, Alejandro Cruz, Vladislav Aksenov, Alexey Golovanov, José M. Lluch, Hartmut Kuhn, Àngels González-Lafont, Igor Ivanov
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
eicosanoids
lipoxygenase inhibitors
protein–protein interactions
allosteric inhibition
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/28/14/5418

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