Statin use and risk of diabetes mellitus
At present time four groups of medications are used to correct dyslipidemia: bile acid sequestrants, niacin, fibric acid derivatives andstatins. During last years statins' potential to increase risk of type 2 diabetes mellitus (T2DM) is actively discussed, though no commonopinion about the poss...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2012-06-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5523 |
| _version_ | 1797255299830120448 |
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| author | Oksana Mikhailovna Drapkina Marina Viktorovna Kostyukevich |
| author_facet | Oksana Mikhailovna Drapkina Marina Viktorovna Kostyukevich |
| author_sort | Oksana Mikhailovna Drapkina |
| collection | DOAJ |
| description | At present time four groups of medications are used to correct dyslipidemia: bile acid sequestrants, niacin, fibric acid derivatives andstatins. During last years statins' potential to increase risk of type 2 diabetes mellitus (T2DM) is actively discussed, though no commonopinion about the possible mechanism of such effect has evolved as yet. Insulin desensitizing effect as a class feature of statins remainsa disputable question.Position of statins as a first-line therapy for severe hyperlipidemia seems undoubted; however they do not improve insulin sensitivity.Moreover, several studies reported increased risk of T2DM. It is feasible to consider combined treatment (including metformin) inpatients from risk groups for development of T2DM, receiving statins |
| first_indexed | 2024-03-08T15:21:38Z |
| format | Article |
| id | doaj.art-b31942a2c8ca41908837b15aa3f8aa17 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:03:39Z |
| publishDate | 2012-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-b31942a2c8ca41908837b15aa3f8aa172024-03-20T11:47:57ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782012-06-01152778210.14341/2072-0351-55235481Statin use and risk of diabetes mellitusOksana Mikhailovna Drapkina0Marina Viktorovna Kostyukevich1I.M. Sechenov First Moscow State Medical University, MoscowI.M. Sechenov First Moscow State Medical University, MoscowAt present time four groups of medications are used to correct dyslipidemia: bile acid sequestrants, niacin, fibric acid derivatives andstatins. During last years statins' potential to increase risk of type 2 diabetes mellitus (T2DM) is actively discussed, though no commonopinion about the possible mechanism of such effect has evolved as yet. Insulin desensitizing effect as a class feature of statins remainsa disputable question.Position of statins as a first-line therapy for severe hyperlipidemia seems undoubted; however they do not improve insulin sensitivity.Moreover, several studies reported increased risk of T2DM. It is feasible to consider combined treatment (including metformin) inpatients from risk groups for development of T2DM, receiving statinshttps://www.dia-endojournals.ru/jour/article/view/5523statinsinsulin resistancediabetes mellitusatherosclerosismetformin |
| spellingShingle | Oksana Mikhailovna Drapkina Marina Viktorovna Kostyukevich Statin use and risk of diabetes mellitus Сахарный диабет statins insulin resistance diabetes mellitus atherosclerosis metformin |
| title | Statin use and risk of diabetes mellitus |
| title_full | Statin use and risk of diabetes mellitus |
| title_fullStr | Statin use and risk of diabetes mellitus |
| title_full_unstemmed | Statin use and risk of diabetes mellitus |
| title_short | Statin use and risk of diabetes mellitus |
| title_sort | statin use and risk of diabetes mellitus |
| topic | statins insulin resistance diabetes mellitus atherosclerosis metformin |
| url | https://www.dia-endojournals.ru/jour/article/view/5523 |
| work_keys_str_mv | AT oksanamikhailovnadrapkina statinuseandriskofdiabetesmellitus AT marinaviktorovnakostyukevich statinuseandriskofdiabetesmellitus |