Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patterns
The cerebellar nuclei are involved in several brain functions, including the modulation of motor and cognitive performance. To differentiate their participation in these functions, and to analyze their changes in neurodegenerative and other diseases as revealed by neuroimaging, stereotaxic maps are...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-05-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00054/full |
| _version_ | 1828749966195032064 |
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| author | Stefanie eTellmann Stefanie eTellmann Sebastian eBludau Simon B. Eickhoff Simon B. Eickhoff Hartmut eMohlberg Martina eMinnerop Katrin eAmunts Katrin eAmunts |
| author_facet | Stefanie eTellmann Stefanie eTellmann Sebastian eBludau Simon B. Eickhoff Simon B. Eickhoff Hartmut eMohlberg Martina eMinnerop Katrin eAmunts Katrin eAmunts |
| author_sort | Stefanie eTellmann |
| collection | DOAJ |
| description | The cerebellar nuclei are involved in several brain functions, including the modulation of motor and cognitive performance. To differentiate their participation in these functions, and to analyze their changes in neurodegenerative and other diseases as revealed by neuroimaging, stereotaxic maps are necessary. These maps reflect the complex spatial structure of cerebellar nuclei with adequate spatial resolution and detail. Here we report on the cytoarchitecture of the dentate, interposed (emboliform and globose) and fastigial nuclei, and introduce 3D probability maps in stereotaxic MNI-Colin27 space as a prerequisite for subsequent meta-analysis of their functional involvement. Histological sections of ten human post mortem brains were therefore examined. Differences in cell density were measured and used to distinguish a dorsal from a ventral part of the dentate nucleus. Probabilistic maps were calculated, which indicate the position and extent of the nuclei in 3D-space, while considering their intersubject variability. The maps of the interposed and the dentate nuclei differed with respect to their interaction patterns and functions based on meta-analytic connectivity modelling and quantitative functional decoding, respectively. For the dentate nucleus, significant (p < 0.05) co-activations were observed with thalamus, supplementary motor area (SMA), putamen, BA 44 of Broca’s region, areas of superior and inferior parietal cortex and the superior frontal gyrus (SFG). In contrast, the interposed nucleus showed more limited co-activations with SMA, area 44, putamen and SFG. Thus, the new stereotaxic maps contribute to analyze structure and function of the cerebellum. These maps can be used for anatomically reliable and precise identification of degenerative alteration in MRI-data of patients who suffer from various cerebellar diseases. |
| first_indexed | 2024-12-10T20:31:02Z |
| format | Article |
| id | doaj.art-b3194ad5e876484f907f3278736c4686 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-10T20:31:02Z |
| publishDate | 2015-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-b3194ad5e876484f907f3278736c46862022-12-22T01:34:42ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292015-05-01910.3389/fnana.2015.00054141321Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patternsStefanie eTellmann0Stefanie eTellmann1Sebastian eBludau2Simon B. Eickhoff3Simon B. Eickhoff4Hartmut eMohlberg5Martina eMinnerop6Katrin eAmunts7Katrin eAmunts8Research Centre JülichRWTH Aachen and JARA-BrainResearch Centre JülichResearch Centre JülichHeinrich Heine UniversityResearch Centre JülichResearch Centre JülichResearch Centre JülichHeinrich Heine UniversityThe cerebellar nuclei are involved in several brain functions, including the modulation of motor and cognitive performance. To differentiate their participation in these functions, and to analyze their changes in neurodegenerative and other diseases as revealed by neuroimaging, stereotaxic maps are necessary. These maps reflect the complex spatial structure of cerebellar nuclei with adequate spatial resolution and detail. Here we report on the cytoarchitecture of the dentate, interposed (emboliform and globose) and fastigial nuclei, and introduce 3D probability maps in stereotaxic MNI-Colin27 space as a prerequisite for subsequent meta-analysis of their functional involvement. Histological sections of ten human post mortem brains were therefore examined. Differences in cell density were measured and used to distinguish a dorsal from a ventral part of the dentate nucleus. Probabilistic maps were calculated, which indicate the position and extent of the nuclei in 3D-space, while considering their intersubject variability. The maps of the interposed and the dentate nuclei differed with respect to their interaction patterns and functions based on meta-analytic connectivity modelling and quantitative functional decoding, respectively. For the dentate nucleus, significant (p < 0.05) co-activations were observed with thalamus, supplementary motor area (SMA), putamen, BA 44 of Broca’s region, areas of superior and inferior parietal cortex and the superior frontal gyrus (SFG). In contrast, the interposed nucleus showed more limited co-activations with SMA, area 44, putamen and SFG. Thus, the new stereotaxic maps contribute to analyze structure and function of the cerebellum. These maps can be used for anatomically reliable and precise identification of degenerative alteration in MRI-data of patients who suffer from various cerebellar diseases.http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00054/fullBrain MappingCerebellar NucleiCytoarchitecturehuman brain atlasSPM Anatomy Toolbox |
| spellingShingle | Stefanie eTellmann Stefanie eTellmann Sebastian eBludau Simon B. Eickhoff Simon B. Eickhoff Hartmut eMohlberg Martina eMinnerop Katrin eAmunts Katrin eAmunts Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patterns Frontiers in Neuroanatomy Brain Mapping Cerebellar Nuclei Cytoarchitecture human brain atlas SPM Anatomy Toolbox |
| title | Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patterns |
| title_full | Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patterns |
| title_fullStr | Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patterns |
| title_full_unstemmed | Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patterns |
| title_short | Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patterns |
| title_sort | cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co activation patterns |
| topic | Brain Mapping Cerebellar Nuclei Cytoarchitecture human brain atlas SPM Anatomy Toolbox |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00054/full |
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