Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides
Lasso peptides are a subclass of ribosomally synthesized and post-translationally modified peptides (RiPPs) and feature the threaded, lariat knot-like topology. The basic post-translational modifications (PTMs) of lasso peptide contain two steps, including the leader peptide removal of the ribosome-...
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7231 |
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| author | Yuwei Duan Weijing Niu Linlin Pang Xiaoying Bian Youming Zhang Guannan Zhong |
| author_facet | Yuwei Duan Weijing Niu Linlin Pang Xiaoying Bian Youming Zhang Guannan Zhong |
| author_sort | Yuwei Duan |
| collection | DOAJ |
| description | Lasso peptides are a subclass of ribosomally synthesized and post-translationally modified peptides (RiPPs) and feature the threaded, lariat knot-like topology. The basic post-translational modifications (PTMs) of lasso peptide contain two steps, including the leader peptide removal of the ribosome-derived linear precursor peptide by an ATP-dependent cysteine protease, and the macrolactam cyclization by an ATP-dependent macrolactam synthetase. Recently, advanced bioinformatic tools combined with genome mining have paved the way to uncover a rapidly growing number of lasso peptides as well as a series of PTMs other than the general class-defining processes. Despite abundant reviews focusing on lasso peptide discoveries, structures, properties, and physiological functionalities, few summaries concerned their unique PTMs. In this review, we summarized all the unique PTMs of lasso peptides uncovered to date, shedding light on the related investigations in the future. |
| first_indexed | 2024-03-09T21:49:13Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:49:13Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b31983bd50cd423e9b5a440ea82afdd22023-11-23T20:10:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313723110.3390/ijms23137231Unusual Post-Translational Modifications in the Biosynthesis of Lasso PeptidesYuwei Duan0Weijing Niu1Linlin Pang2Xiaoying Bian3Youming Zhang4Guannan Zhong5Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, ChinaHelmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, ChinaHelmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, ChinaHelmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, ChinaHelmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, ChinaHelmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, ChinaLasso peptides are a subclass of ribosomally synthesized and post-translationally modified peptides (RiPPs) and feature the threaded, lariat knot-like topology. The basic post-translational modifications (PTMs) of lasso peptide contain two steps, including the leader peptide removal of the ribosome-derived linear precursor peptide by an ATP-dependent cysteine protease, and the macrolactam cyclization by an ATP-dependent macrolactam synthetase. Recently, advanced bioinformatic tools combined with genome mining have paved the way to uncover a rapidly growing number of lasso peptides as well as a series of PTMs other than the general class-defining processes. Despite abundant reviews focusing on lasso peptide discoveries, structures, properties, and physiological functionalities, few summaries concerned their unique PTMs. In this review, we summarized all the unique PTMs of lasso peptides uncovered to date, shedding light on the related investigations in the future.https://www.mdpi.com/1422-0067/23/13/7231lasso peptidespost-translational modificationsbiosynthesisRiPPsnatural products |
| spellingShingle | Yuwei Duan Weijing Niu Linlin Pang Xiaoying Bian Youming Zhang Guannan Zhong Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides International Journal of Molecular Sciences lasso peptides post-translational modifications biosynthesis RiPPs natural products |
| title | Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides |
| title_full | Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides |
| title_fullStr | Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides |
| title_full_unstemmed | Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides |
| title_short | Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides |
| title_sort | unusual post translational modifications in the biosynthesis of lasso peptides |
| topic | lasso peptides post-translational modifications biosynthesis RiPPs natural products |
| url | https://www.mdpi.com/1422-0067/23/13/7231 |
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