A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation
NODAT (new-onset diabetes after transplantation) is an important complication after liver transplant, however, there is variation in the reported incidence of NODAT. Therefore, a meta-analysis was performed to estimate the incidence of NODAT in liver transplant. Electronic databases were searched fo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/5/1045 |
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| author | Yip Han Chin Hon Qin Marcus Tan Cheng Han Ng Darren Jun Hao Tan Snow Yunni Lin Daniel Q. Huang Chin Meng Khoo Mark Dhinesh Muthiah |
| author_facet | Yip Han Chin Hon Qin Marcus Tan Cheng Han Ng Darren Jun Hao Tan Snow Yunni Lin Daniel Q. Huang Chin Meng Khoo Mark Dhinesh Muthiah |
| author_sort | Yip Han Chin |
| collection | DOAJ |
| description | NODAT (new-onset diabetes after transplantation) is an important complication after liver transplant, however, there is variation in the reported incidence of NODAT. Therefore, a meta-analysis was performed to estimate the incidence of NODAT in liver transplant. Electronic databases were searched for articles regarding NODAT incidence after liver transplantation. Incidence of NODAT were analyzed at six different timepoints. Summary statistics were calculated using a generalized linear mixed model in random effects. 28 articles were included and out of a pooled population of 71,257 patients, overall incidence of NODAT was found to be 15.51%, 16.09%, 18.30%, 20.86%, 18.08%, 25.05% for three-months, six-months, one-year, three-year, five-year, and ten-year timepoints respectively. After a sensitivity analysis which only included articles with clear definitions of NODAT, the incidence of NODAT was found to be higher at three-year (21.79%), five-year (25.82%), and ten-year (44.95%) timepoints. Subgroup analysis according to ethnicity found no significant differences for all timepoints. However, studies with predominantly Asian participants generally had a higher incidence of NODAT. In conclusion, this meta-analysis provides a pooled estimate of the incidence of NODAT following liver transplantation. Further studies are required to provide a more comprehensive understanding on how ethnicity can affect the incidence of NODAT. |
| first_indexed | 2024-03-09T05:47:25Z |
| format | Article |
| id | doaj.art-b319d9839cd64742a03f58a23c74ab31 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T05:47:25Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b319d9839cd64742a03f58a23c74ab312023-12-03T12:20:22ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01105104510.3390/jcm10051045A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver TransplantationYip Han Chin0Hon Qin Marcus Tan1Cheng Han Ng2Darren Jun Hao Tan3Snow Yunni Lin4Daniel Q. Huang5Chin Meng Khoo6Mark Dhinesh Muthiah7Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeNODAT (new-onset diabetes after transplantation) is an important complication after liver transplant, however, there is variation in the reported incidence of NODAT. Therefore, a meta-analysis was performed to estimate the incidence of NODAT in liver transplant. Electronic databases were searched for articles regarding NODAT incidence after liver transplantation. Incidence of NODAT were analyzed at six different timepoints. Summary statistics were calculated using a generalized linear mixed model in random effects. 28 articles were included and out of a pooled population of 71,257 patients, overall incidence of NODAT was found to be 15.51%, 16.09%, 18.30%, 20.86%, 18.08%, 25.05% for three-months, six-months, one-year, three-year, five-year, and ten-year timepoints respectively. After a sensitivity analysis which only included articles with clear definitions of NODAT, the incidence of NODAT was found to be higher at three-year (21.79%), five-year (25.82%), and ten-year (44.95%) timepoints. Subgroup analysis according to ethnicity found no significant differences for all timepoints. However, studies with predominantly Asian participants generally had a higher incidence of NODAT. In conclusion, this meta-analysis provides a pooled estimate of the incidence of NODAT following liver transplantation. Further studies are required to provide a more comprehensive understanding on how ethnicity can affect the incidence of NODAT.https://www.mdpi.com/2077-0383/10/5/1045NODATliver transplantationnew onset diabetes after transplantationtype 2 diabetesincidence |
| spellingShingle | Yip Han Chin Hon Qin Marcus Tan Cheng Han Ng Darren Jun Hao Tan Snow Yunni Lin Daniel Q. Huang Chin Meng Khoo Mark Dhinesh Muthiah A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation Journal of Clinical Medicine NODAT liver transplantation new onset diabetes after transplantation type 2 diabetes incidence |
| title | A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation |
| title_full | A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation |
| title_fullStr | A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation |
| title_full_unstemmed | A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation |
| title_short | A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation |
| title_sort | time based meta analysis on the incidence of new onset diabetes after liver transplantation |
| topic | NODAT liver transplantation new onset diabetes after transplantation type 2 diabetes incidence |
| url | https://www.mdpi.com/2077-0383/10/5/1045 |
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