The role of cholesterol metabolism in tumor therapy, from bench to bed
Cholesterol and its metabolites have important biological functions. Cholesterol is able to maintain the physical properties of cell membrane, play an important role in cellular signaling, and cellular cholesterol levels reflect the dynamic balance between biosynthesis, uptake, efflux and esterifica...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.928821/full |
| _version_ | 1797851460642275328 |
|---|---|
| author | Wenhao Xia Wenhao Xia Hao Wang Hao Wang Xiaozhu Zhou Yan Wang Yan Wang Lixiang Xue Lixiang Xue Lixiang Xue Baoshan Cao Baoshan Cao Jiagui Song Jiagui Song Jiagui Song |
| author_facet | Wenhao Xia Wenhao Xia Hao Wang Hao Wang Xiaozhu Zhou Yan Wang Yan Wang Lixiang Xue Lixiang Xue Lixiang Xue Baoshan Cao Baoshan Cao Jiagui Song Jiagui Song Jiagui Song |
| author_sort | Wenhao Xia |
| collection | DOAJ |
| description | Cholesterol and its metabolites have important biological functions. Cholesterol is able to maintain the physical properties of cell membrane, play an important role in cellular signaling, and cellular cholesterol levels reflect the dynamic balance between biosynthesis, uptake, efflux and esterification. Cholesterol metabolism participates in bile acid production and steroid hormone biosynthesis. Increasing evidence suggests a strict link between cholesterol homeostasis and tumors. Cholesterol metabolism in tumor cells is reprogrammed to differ significantly from normal cells, and disturbances of cholesterol balance also induce tumorigenesis and progression. Preclinical and clinical studies have shown that controlling cholesterol metabolism suppresses tumor growth, suggesting that targeting cholesterol metabolism may provide new possibilities for tumor therapy. In this review, we summarized the metabolic pathways of cholesterol in normal and tumor cells and reviewed the pre-clinical and clinical progression of novel tumor therapeutic strategy with the drugs targeting different stages of cholesterol metabolism from bench to bedside. |
| first_indexed | 2024-04-09T19:17:08Z |
| format | Article |
| id | doaj.art-b31b9ec8f5a74d3cb549d81e58dbb0e0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T19:17:08Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b31b9ec8f5a74d3cb549d81e58dbb0e02023-04-06T04:44:41ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.928821928821The role of cholesterol metabolism in tumor therapy, from bench to bedWenhao Xia0Wenhao Xia1Hao Wang2Hao Wang3Xiaozhu Zhou4Yan Wang5Yan Wang6Lixiang Xue7Lixiang Xue8Lixiang Xue9Baoshan Cao10Baoshan Cao11Jiagui Song12Jiagui Song13Jiagui Song14Cancer Center of Peking University Third Hospital, Beijing, ChinaSchool of Basic Medical Sciences, Peking University Health Science Center, Beijing, ChinaCancer Center of Peking University Third Hospital, Beijing, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, ChinaDepartment of Clinical Pharmacy, School of Pharmacy, Capital Medical University, Beijing, ChinaCancer Center of Peking University Third Hospital, Beijing, ChinaThird Hospital Institute of Medical Innovation and Research, Beijing, ChinaCancer Center of Peking University Third Hospital, Beijing, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, ChinaThird Hospital Institute of Medical Innovation and Research, Beijing, ChinaCancer Center of Peking University Third Hospital, Beijing, ChinaDepartment of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, ChinaCancer Center of Peking University Third Hospital, Beijing, ChinaThird Hospital Institute of Medical Innovation and Research, Beijing, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University as the Third Responsibility Unit of Song Jiagui, Beijing, ChinaCholesterol and its metabolites have important biological functions. Cholesterol is able to maintain the physical properties of cell membrane, play an important role in cellular signaling, and cellular cholesterol levels reflect the dynamic balance between biosynthesis, uptake, efflux and esterification. Cholesterol metabolism participates in bile acid production and steroid hormone biosynthesis. Increasing evidence suggests a strict link between cholesterol homeostasis and tumors. Cholesterol metabolism in tumor cells is reprogrammed to differ significantly from normal cells, and disturbances of cholesterol balance also induce tumorigenesis and progression. Preclinical and clinical studies have shown that controlling cholesterol metabolism suppresses tumor growth, suggesting that targeting cholesterol metabolism may provide new possibilities for tumor therapy. In this review, we summarized the metabolic pathways of cholesterol in normal and tumor cells and reviewed the pre-clinical and clinical progression of novel tumor therapeutic strategy with the drugs targeting different stages of cholesterol metabolism from bench to bedside.https://www.frontiersin.org/articles/10.3389/fphar.2023.928821/fullcholesterolcholesterol metabolismtumor therapypharmacological targetsclinical trial |
| spellingShingle | Wenhao Xia Wenhao Xia Hao Wang Hao Wang Xiaozhu Zhou Yan Wang Yan Wang Lixiang Xue Lixiang Xue Lixiang Xue Baoshan Cao Baoshan Cao Jiagui Song Jiagui Song Jiagui Song The role of cholesterol metabolism in tumor therapy, from bench to bed Frontiers in Pharmacology cholesterol cholesterol metabolism tumor therapy pharmacological targets clinical trial |
| title | The role of cholesterol metabolism in tumor therapy, from bench to bed |
| title_full | The role of cholesterol metabolism in tumor therapy, from bench to bed |
| title_fullStr | The role of cholesterol metabolism in tumor therapy, from bench to bed |
| title_full_unstemmed | The role of cholesterol metabolism in tumor therapy, from bench to bed |
| title_short | The role of cholesterol metabolism in tumor therapy, from bench to bed |
| title_sort | role of cholesterol metabolism in tumor therapy from bench to bed |
| topic | cholesterol cholesterol metabolism tumor therapy pharmacological targets clinical trial |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.928821/full |
| work_keys_str_mv | AT wenhaoxia theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT wenhaoxia theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT haowang theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT haowang theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT xiaozhuzhou theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT yanwang theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT yanwang theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT lixiangxue theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT lixiangxue theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT lixiangxue theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT baoshancao theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT baoshancao theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT jiaguisong theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT jiaguisong theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT jiaguisong theroleofcholesterolmetabolismintumortherapyfrombenchtobed AT wenhaoxia roleofcholesterolmetabolismintumortherapyfrombenchtobed AT wenhaoxia roleofcholesterolmetabolismintumortherapyfrombenchtobed AT haowang roleofcholesterolmetabolismintumortherapyfrombenchtobed AT haowang roleofcholesterolmetabolismintumortherapyfrombenchtobed AT xiaozhuzhou roleofcholesterolmetabolismintumortherapyfrombenchtobed AT yanwang roleofcholesterolmetabolismintumortherapyfrombenchtobed AT yanwang roleofcholesterolmetabolismintumortherapyfrombenchtobed AT lixiangxue roleofcholesterolmetabolismintumortherapyfrombenchtobed AT lixiangxue roleofcholesterolmetabolismintumortherapyfrombenchtobed AT lixiangxue roleofcholesterolmetabolismintumortherapyfrombenchtobed AT baoshancao roleofcholesterolmetabolismintumortherapyfrombenchtobed AT baoshancao roleofcholesterolmetabolismintumortherapyfrombenchtobed AT jiaguisong roleofcholesterolmetabolismintumortherapyfrombenchtobed AT jiaguisong roleofcholesterolmetabolismintumortherapyfrombenchtobed AT jiaguisong roleofcholesterolmetabolismintumortherapyfrombenchtobed |