Short-term triple therapy with azithromycin for <it>Helicobacter pylori </it>eradication: Low cost, high compliance, but low efficacy
<p>Abstract</p> <p>Background</p> <p>The Brazilian consensus recommends a short-term treatment course with clarithromycin, amoxicillin and proton-pump inhibitor for the eradication of <it>Helicobacter pylori </it>(<it>H. pylori)</it>. This treatm...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-05-01
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| Series: | BMC Gastroenterology |
| Online Access: | http://www.biomedcentral.com/1471-230X/8/20 |
| _version_ | 1831613329955618816 |
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| author | Mattar Rejane Navarro-Rodriguez Tomás Barbuti Ricardo C Teixeira Ana Eisig Jaime N Silva Fernando M |
| author_facet | Mattar Rejane Navarro-Rodriguez Tomás Barbuti Ricardo C Teixeira Ana Eisig Jaime N Silva Fernando M |
| author_sort | Mattar Rejane |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The Brazilian consensus recommends a short-term treatment course with clarithromycin, amoxicillin and proton-pump inhibitor for the eradication of <it>Helicobacter pylori </it>(<it>H. pylori)</it>. This treatment course has good efficacy, but cannot be afforded by a large part of the population. Azithromycin, amoxicillin and omeprazole are subsidized, for several aims, by the Brazilian federal government. Therefore, a short-term treatment course that uses these drugs is a low-cost one, but its efficacy regarding the bacterium eradication is yet to be demonstrated. The study's purpose was to verify the efficacy of <it>H. pylori </it>eradication in infected patients who presented peptic ulcer disease, using the association of azithromycin, amoxicillin and omeprazole.</p> <p>Methods</p> <p>Sixty patients with peptic ulcer diagnosed by upper digestive endoscopy and <it>H. pylori </it>infection documented by rapid urease test, histological analysis and urea breath test were treated for six days with a combination of azithromycin 500 mg and omeprazole 20 mg, in a single daily dose, associated with amoxicillin 500 mg 3 times a day. The eradication control was carried out 12 weeks after the treatment by means of the same diagnostic tests. The eradication rates were calculated with 95% confidence interval.</p> <p>Results</p> <p>The eradication rate was 38% per intention to treat and 41% per protocol. Few adverse effects were observed and treatment compliance was high.</p> <p>Conclusion</p> <p>Despite its low cost and high compliance, the low eradication rate does not allow the recommendation of the triple therapy with azithromycin as an adequate treatment for <it>H. pylori </it>infection.</p> |
| first_indexed | 2024-12-18T19:06:11Z |
| format | Article |
| id | doaj.art-b31d64414d334d13b35451cfb7ccf241 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-18T19:06:11Z |
| publishDate | 2008-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-b31d64414d334d13b35451cfb7ccf2412022-12-21T20:56:25ZengBMCBMC Gastroenterology1471-230X2008-05-01812010.1186/1471-230X-8-20Short-term triple therapy with azithromycin for <it>Helicobacter pylori </it>eradication: Low cost, high compliance, but low efficacyMattar RejaneNavarro-Rodriguez TomásBarbuti Ricardo CTeixeira AnaEisig Jaime NSilva Fernando M<p>Abstract</p> <p>Background</p> <p>The Brazilian consensus recommends a short-term treatment course with clarithromycin, amoxicillin and proton-pump inhibitor for the eradication of <it>Helicobacter pylori </it>(<it>H. pylori)</it>. This treatment course has good efficacy, but cannot be afforded by a large part of the population. Azithromycin, amoxicillin and omeprazole are subsidized, for several aims, by the Brazilian federal government. Therefore, a short-term treatment course that uses these drugs is a low-cost one, but its efficacy regarding the bacterium eradication is yet to be demonstrated. The study's purpose was to verify the efficacy of <it>H. pylori </it>eradication in infected patients who presented peptic ulcer disease, using the association of azithromycin, amoxicillin and omeprazole.</p> <p>Methods</p> <p>Sixty patients with peptic ulcer diagnosed by upper digestive endoscopy and <it>H. pylori </it>infection documented by rapid urease test, histological analysis and urea breath test were treated for six days with a combination of azithromycin 500 mg and omeprazole 20 mg, in a single daily dose, associated with amoxicillin 500 mg 3 times a day. The eradication control was carried out 12 weeks after the treatment by means of the same diagnostic tests. The eradication rates were calculated with 95% confidence interval.</p> <p>Results</p> <p>The eradication rate was 38% per intention to treat and 41% per protocol. Few adverse effects were observed and treatment compliance was high.</p> <p>Conclusion</p> <p>Despite its low cost and high compliance, the low eradication rate does not allow the recommendation of the triple therapy with azithromycin as an adequate treatment for <it>H. pylori </it>infection.</p>http://www.biomedcentral.com/1471-230X/8/20 |
| spellingShingle | Mattar Rejane Navarro-Rodriguez Tomás Barbuti Ricardo C Teixeira Ana Eisig Jaime N Silva Fernando M Short-term triple therapy with azithromycin for <it>Helicobacter pylori </it>eradication: Low cost, high compliance, but low efficacy BMC Gastroenterology |
| title | Short-term triple therapy with azithromycin for <it>Helicobacter pylori </it>eradication: Low cost, high compliance, but low efficacy |
| title_full | Short-term triple therapy with azithromycin for <it>Helicobacter pylori </it>eradication: Low cost, high compliance, but low efficacy |
| title_fullStr | Short-term triple therapy with azithromycin for <it>Helicobacter pylori </it>eradication: Low cost, high compliance, but low efficacy |
| title_full_unstemmed | Short-term triple therapy with azithromycin for <it>Helicobacter pylori </it>eradication: Low cost, high compliance, but low efficacy |
| title_short | Short-term triple therapy with azithromycin for <it>Helicobacter pylori </it>eradication: Low cost, high compliance, but low efficacy |
| title_sort | short term triple therapy with azithromycin for it helicobacter pylori it eradication low cost high compliance but low efficacy |
| url | http://www.biomedcentral.com/1471-230X/8/20 |
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