Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults
BackgroundAge-related muscle mass and function decline are critical issues that have gained attention in clinical practice and research. Nevertheless, little is known regarding the time course of muscle health progression, and its determinants during this transition should be estimated.MethodsWe enr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.817044/full |
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| author | Yuan-Ping Chao Yuan-Ping Chao Wen-Hui Fang Wen-Hui Fang Wei-Liang Chen Wei-Liang Chen Wei-Liang Chen Tao-Chun Peng Tao-Chun Peng Wei-Shiung Yang Wei-Shiung Yang Wei-Shiung Yang Tung-Wei Kao Tung-Wei Kao Tung-Wei Kao |
| author_facet | Yuan-Ping Chao Yuan-Ping Chao Wen-Hui Fang Wen-Hui Fang Wei-Liang Chen Wei-Liang Chen Wei-Liang Chen Tao-Chun Peng Tao-Chun Peng Wei-Shiung Yang Wei-Shiung Yang Wei-Shiung Yang Tung-Wei Kao Tung-Wei Kao Tung-Wei Kao |
| author_sort | Yuan-Ping Chao |
| collection | DOAJ |
| description | BackgroundAge-related muscle mass and function decline are critical issues that have gained attention in clinical practice and research. Nevertheless, little is known regarding the time course of muscle health progression, and its determinants during this transition should be estimated.MethodsWe enrolled community-dwelling adults aged ≥65 years during their regular health checkup. The participants’ body composition and muscle function were measured annually from 2015 to 2021. Presarcopenia was characterized by the loss of muscle mass only; dynapenia was defined as low muscle function without changes in muscle mass; and sarcopenia was indicated as a decline in both muscle mass and muscle function. We observed the natural course of muscle health progression during aging. The relationship between muscle health decline and different determinants among old adults was examined.ResultsAmong 568 participants, there was 18.49%, 3.52%, and 1.06% of healthy individuals transited to dynapenia, presarcopenia, and sarcopenia, respectively. Significant positive correlations between age, fat-to-muscle ratio (FMR) and the dynapenia transition were existed [hazard ratio (HR) = 1.08 and HR = 1.73, all p < 0.05]. Serum albumin level had negative correlation with the dynapenia transition risk (HR = 0.30, p = 0.004). Participants with these three risk factors had the highest HR of dynapenia transition compared to those without (HR = 8.67, p = 0.001). A dose-response effect existed between risk factors numbers and the risk of dynapenia transition (p for trend < 0.001). This positive association and dose-response relationship remains after multiple covariates adjustment (HR = 7.74, p = 0.002, p for trend < 0.001). Participants with two or more than two risk factors had a higher risk of dynapenia transition than those with low risk factors (p = 0.0027), and the HR was 1.96 after multiple covariate adjustment (p = 0.029).ConclusionHealthy community-dwelling old adults tended to transit to dynapenia during muscle health deterioration. Individuals with older age, higher FMR, lower albumin level had a higher risk of dynapenia transition; and a positive dose-response effect existed among this population as well. |
| first_indexed | 2024-04-14T06:48:46Z |
| format | Article |
| id | doaj.art-b31deaec20144e56b5307320c5a39846 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-14T06:48:46Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-b31deaec20144e56b5307320c5a398462022-12-22T02:07:06ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-04-01910.3389/fnut.2022.817044817044Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older AdultsYuan-Ping Chao0Yuan-Ping Chao1Wen-Hui Fang2Wen-Hui Fang3Wei-Liang Chen4Wei-Liang Chen5Wei-Liang Chen6Tao-Chun Peng7Tao-Chun Peng8Wei-Shiung Yang9Wei-Shiung Yang10Wei-Shiung Yang11Tung-Wei Kao12Tung-Wei Kao13Tung-Wei Kao14Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, TaiwanDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanCenter for Obesity, Life Style and Metabolic Surgery, National Taiwan University Hospital, Taipei, TaiwanDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, TaiwanBackgroundAge-related muscle mass and function decline are critical issues that have gained attention in clinical practice and research. Nevertheless, little is known regarding the time course of muscle health progression, and its determinants during this transition should be estimated.MethodsWe enrolled community-dwelling adults aged ≥65 years during their regular health checkup. The participants’ body composition and muscle function were measured annually from 2015 to 2021. Presarcopenia was characterized by the loss of muscle mass only; dynapenia was defined as low muscle function without changes in muscle mass; and sarcopenia was indicated as a decline in both muscle mass and muscle function. We observed the natural course of muscle health progression during aging. The relationship between muscle health decline and different determinants among old adults was examined.ResultsAmong 568 participants, there was 18.49%, 3.52%, and 1.06% of healthy individuals transited to dynapenia, presarcopenia, and sarcopenia, respectively. Significant positive correlations between age, fat-to-muscle ratio (FMR) and the dynapenia transition were existed [hazard ratio (HR) = 1.08 and HR = 1.73, all p < 0.05]. Serum albumin level had negative correlation with the dynapenia transition risk (HR = 0.30, p = 0.004). Participants with these three risk factors had the highest HR of dynapenia transition compared to those without (HR = 8.67, p = 0.001). A dose-response effect existed between risk factors numbers and the risk of dynapenia transition (p for trend < 0.001). This positive association and dose-response relationship remains after multiple covariates adjustment (HR = 7.74, p = 0.002, p for trend < 0.001). Participants with two or more than two risk factors had a higher risk of dynapenia transition than those with low risk factors (p = 0.0027), and the HR was 1.96 after multiple covariate adjustment (p = 0.029).ConclusionHealthy community-dwelling old adults tended to transit to dynapenia during muscle health deterioration. Individuals with older age, higher FMR, lower albumin level had a higher risk of dynapenia transition; and a positive dose-response effect existed among this population as well.https://www.frontiersin.org/articles/10.3389/fnut.2022.817044/fullsarcopeniatransitionmuscle functionfat-to-muscle ratiodynapenia |
| spellingShingle | Yuan-Ping Chao Yuan-Ping Chao Wen-Hui Fang Wen-Hui Fang Wei-Liang Chen Wei-Liang Chen Wei-Liang Chen Tao-Chun Peng Tao-Chun Peng Wei-Shiung Yang Wei-Shiung Yang Wei-Shiung Yang Tung-Wei Kao Tung-Wei Kao Tung-Wei Kao Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults Frontiers in Nutrition sarcopenia transition muscle function fat-to-muscle ratio dynapenia |
| title | Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults |
| title_full | Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults |
| title_fullStr | Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults |
| title_full_unstemmed | Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults |
| title_short | Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults |
| title_sort | exploring muscle health deterioration and its determinants among community dwelling older adults |
| topic | sarcopenia transition muscle function fat-to-muscle ratio dynapenia |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.817044/full |
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