Fertility-sparing treatment for endometrial cancer and atypical endometrial hyperplasia in patients with Lynch Syndrome: Molecular diagnosis after immunohistochemistry of MMR proteins

Fertility-sparing treatment for endometrial cancer and atypical endometrial hyperplasia in patients with Lynch Syndrome: Molecular diagnosis after immunohistochemistry of MMR proteins

IntroductionLynch Syndrome (LS) represents the hereditary condition that is most frequently associated with endometrial cancer (EC). The aim of this study is to assess the presence of Lynch Syndrome (LS) in young women with mismatch repair (MMR)-deficient atypical endometrial hyperplasia (AEH) and n...

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Main Authors: Ursula Catena, Luigi Della Corte, Antonio Raffone, Antonio Travaglino, Emanuela Lucci Cordisco, Elena Teodorico, Valeria Masciullo, Giuseppe Bifulco, Attilio Di Spiezio Sardo, Giovanni Scambia, Francesco Fanfani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Medicine
Subjects:
endometrial cancer
Lynch Syndrome
fertility-sparing treatment
immunohistochemistry
mismatch repair
genetic testing
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.948509/full

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