MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin‐Producing Reparative Macrophages After Myocardial Infarction

MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin‐Producing Reparative Macrophages After Myocardial Infarction

Background We previously reported that osteopontin plays an essential role in accelerating both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after myocardial infarction (MI) and galectin‐3hiCD206+ macrophages is the main source of osteopontin in post‐MI heart....

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Bibliographic Details
Main Authors: Kohsuke Shirakawa, Jin Endo, Masaharu Kataoka, Yoshinori Katsumata, Atsushi Anzai, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Seien Ko, Shinichi Goto, Genki Ichihara, Keiichi Fukuda, Tohru Minamino, Motoaki Sano
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
galectin‐3
macrophage
macrophage colony‐stimulating factor
MerTK
myocardial infarction
osteopontin
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.017071

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