Predictors of one-year mortality after hospitalization for an exacerbation of COPD
Abstract Background Hospitalization for a severe exacerbation of COPD (eCOPD) is an important event in the natural history of COPD. Identifying factors related to mortality 1 year after hospitalization could help determine interventions to reduce mortality. Methods In a prospective, observational, m...
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12890-018-0574-z |
| _version_ | 1819055608771379200 |
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| author | Cristóbal Esteban Ady Castro-Acosta Carlos Jose Alvarez-Martínez Alberto Capelastegui José Luis López-Campos Francisco Pozo-Rodriguez |
| author_facet | Cristóbal Esteban Ady Castro-Acosta Carlos Jose Alvarez-Martínez Alberto Capelastegui José Luis López-Campos Francisco Pozo-Rodriguez |
| author_sort | Cristóbal Esteban |
| collection | DOAJ |
| description | Abstract Background Hospitalization for a severe exacerbation of COPD (eCOPD) is an important event in the natural history of COPD. Identifying factors related to mortality 1 year after hospitalization could help determine interventions to reduce mortality. Methods In a prospective, observational, multicentre study, we evaluated data from two cohorts: the Spanish audit of hospital COPD exacerbation care (our derivation sample) and the Spanish cohort of the European audit of COPD exacerbation care (our validation sample). The endpoint was all-cause mortality. Mortality was determined by local research managers of the participating hospitals and matched the official national index records in Spain. Results In the multivariate analysis, factors independently related to an increase in mortality were older age, cardio-cerebro-vascular and/or dementia comorbidities, PaCO2 > 55 mmHg measured at emergency department arrival, hospitalizations for COPD exacerbations in the previous year, and hospital characteristics. The area under the receiver-operating curve for this model was 0.75 in the derivation cohort and 0.76 in the validation cohort. Conclusion One-year mortality following the index hospitalization for an exacerbation of COPD was related to clinical characteristics of the patient and of the index event, previous events of similar severity, and characteristics of the hospital where the patient was treated. |
| first_indexed | 2024-12-21T13:10:14Z |
| format | Article |
| id | doaj.art-b31efac87b6946daadcdbdb6e9788282 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-21T13:10:14Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-b31efac87b6946daadcdbdb6e97882822022-12-21T19:02:55ZengBMCBMC Pulmonary Medicine1471-24662018-01-0118111010.1186/s12890-018-0574-zPredictors of one-year mortality after hospitalization for an exacerbation of COPDCristóbal Esteban0Ady Castro-Acosta1Carlos Jose Alvarez-Martínez2Alberto Capelastegui3José Luis López-Campos4Francisco Pozo-Rodriguez5Pulmonary Service, Galdakao-Usansolo HospitalPulmonary Service and Research Institute, Doce de Octubre University HospitalPulmonary Service and Research Institute, Doce de Octubre University HospitalPulmonary Service, Galdakao-Usansolo HospitalHospital Universitario Virgen del Rocío, Medical- Surgical Unit of Respiratory DiseasesPulmonary Service and Research Institute, Doce de Octubre University HospitalAbstract Background Hospitalization for a severe exacerbation of COPD (eCOPD) is an important event in the natural history of COPD. Identifying factors related to mortality 1 year after hospitalization could help determine interventions to reduce mortality. Methods In a prospective, observational, multicentre study, we evaluated data from two cohorts: the Spanish audit of hospital COPD exacerbation care (our derivation sample) and the Spanish cohort of the European audit of COPD exacerbation care (our validation sample). The endpoint was all-cause mortality. Mortality was determined by local research managers of the participating hospitals and matched the official national index records in Spain. Results In the multivariate analysis, factors independently related to an increase in mortality were older age, cardio-cerebro-vascular and/or dementia comorbidities, PaCO2 > 55 mmHg measured at emergency department arrival, hospitalizations for COPD exacerbations in the previous year, and hospital characteristics. The area under the receiver-operating curve for this model was 0.75 in the derivation cohort and 0.76 in the validation cohort. Conclusion One-year mortality following the index hospitalization for an exacerbation of COPD was related to clinical characteristics of the patient and of the index event, previous events of similar severity, and characteristics of the hospital where the patient was treated.http://link.springer.com/article/10.1186/s12890-018-0574-zPulmonary diseaseChronic obstructiveHospitalizationMortality |
| spellingShingle | Cristóbal Esteban Ady Castro-Acosta Carlos Jose Alvarez-Martínez Alberto Capelastegui José Luis López-Campos Francisco Pozo-Rodriguez Predictors of one-year mortality after hospitalization for an exacerbation of COPD BMC Pulmonary Medicine Pulmonary disease Chronic obstructive Hospitalization Mortality |
| title | Predictors of one-year mortality after hospitalization for an exacerbation of COPD |
| title_full | Predictors of one-year mortality after hospitalization for an exacerbation of COPD |
| title_fullStr | Predictors of one-year mortality after hospitalization for an exacerbation of COPD |
| title_full_unstemmed | Predictors of one-year mortality after hospitalization for an exacerbation of COPD |
| title_short | Predictors of one-year mortality after hospitalization for an exacerbation of COPD |
| title_sort | predictors of one year mortality after hospitalization for an exacerbation of copd |
| topic | Pulmonary disease Chronic obstructive Hospitalization Mortality |
| url | http://link.springer.com/article/10.1186/s12890-018-0574-z |
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