Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients.
Lactoferrin (Lf) is an important protein found on mucosal surfaces, within neutrophils and various cells, and in biological fluids. It displays multiple functions, including iron-binding as well as antimicrobial, immunomodulatory and anti-inflammatory activities. Although Lf ingestion has been sugge...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5130198?pdf=render |
| _version_ | 1811233024083230720 |
|---|---|
| author | Sylvain Mayeur Alain Veilleux Yves Pouliot Benoît Lamarche Jean-François Beaulieu Frédéric S Hould Denis Richard André Tchernof Emile Levy |
| author_facet | Sylvain Mayeur Alain Veilleux Yves Pouliot Benoît Lamarche Jean-François Beaulieu Frédéric S Hould Denis Richard André Tchernof Emile Levy |
| author_sort | Sylvain Mayeur |
| collection | DOAJ |
| description | Lactoferrin (Lf) is an important protein found on mucosal surfaces, within neutrophils and various cells, and in biological fluids. It displays multiple functions, including iron-binding as well as antimicrobial, immunomodulatory and anti-inflammatory activities. Although Lf ingestion has been suggested to cause adiposity reduction in murine models and humans, its relationship with insulin resistance (IR) has not been studied thoroughly.To establish the association between circulating Lf levels, glucose status and blood lipid/lipoprotein profile.Two independent cohorts were examined: lean to moderately obese women admitted for gynecological surgery (n = 53) and severely obese subjects undergoing biliopancreatic diversion (n = 62).Although body mass index (BMI) and total body fat mass were negatively associated with Lf, IR (assessed by the HOMA-IR index) was positively and independently associated with plasma Lf concentrations of the first cohort of lean to moderately obese women. These observations were validated in the second cohort in view of the positive correlation between plasma Lf concentrations and the HOMA-IR index, but without a significant association with the body mass index (BMI) of severely obese subjects. In subsamples of severely obese subjects matched for sex, age and BMI, but with either relatively low (1.89 ± 0.73) or high (13.77 ± 8.81) IR states (according to HOMA-IR), higher plasma Lf levels were noted in insulin-resistant vs insulin-sensitive subjects (P<0.05). Finally, Lf levels were significantly higher in lean to moderately obese women than in severely obese subjects (P<0.05).Our findings revealed that plasma Lf levels are strongly associated with IR independently of total adiposity, which suggests an intriguing Lf regulation mechanism in conditions of obesity and IR. |
| first_indexed | 2024-04-12T11:13:53Z |
| format | Article |
| id | doaj.art-b31f02c2650e459cb8ad9b58e98ef104 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T11:13:53Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b31f02c2650e459cb8ad9b58e98ef1042022-12-22T03:35:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016613810.1371/journal.pone.0166138Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients.Sylvain MayeurAlain VeilleuxYves PouliotBenoît LamarcheJean-François BeaulieuFrédéric S HouldDenis RichardAndré TchernofEmile LevyLactoferrin (Lf) is an important protein found on mucosal surfaces, within neutrophils and various cells, and in biological fluids. It displays multiple functions, including iron-binding as well as antimicrobial, immunomodulatory and anti-inflammatory activities. Although Lf ingestion has been suggested to cause adiposity reduction in murine models and humans, its relationship with insulin resistance (IR) has not been studied thoroughly.To establish the association between circulating Lf levels, glucose status and blood lipid/lipoprotein profile.Two independent cohorts were examined: lean to moderately obese women admitted for gynecological surgery (n = 53) and severely obese subjects undergoing biliopancreatic diversion (n = 62).Although body mass index (BMI) and total body fat mass were negatively associated with Lf, IR (assessed by the HOMA-IR index) was positively and independently associated with plasma Lf concentrations of the first cohort of lean to moderately obese women. These observations were validated in the second cohort in view of the positive correlation between plasma Lf concentrations and the HOMA-IR index, but without a significant association with the body mass index (BMI) of severely obese subjects. In subsamples of severely obese subjects matched for sex, age and BMI, but with either relatively low (1.89 ± 0.73) or high (13.77 ± 8.81) IR states (according to HOMA-IR), higher plasma Lf levels were noted in insulin-resistant vs insulin-sensitive subjects (P<0.05). Finally, Lf levels were significantly higher in lean to moderately obese women than in severely obese subjects (P<0.05).Our findings revealed that plasma Lf levels are strongly associated with IR independently of total adiposity, which suggests an intriguing Lf regulation mechanism in conditions of obesity and IR.http://europepmc.org/articles/PMC5130198?pdf=render |
| spellingShingle | Sylvain Mayeur Alain Veilleux Yves Pouliot Benoît Lamarche Jean-François Beaulieu Frédéric S Hould Denis Richard André Tchernof Emile Levy Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients. PLoS ONE |
| title | Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients. |
| title_full | Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients. |
| title_fullStr | Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients. |
| title_full_unstemmed | Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients. |
| title_short | Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients. |
| title_sort | plasma lactoferrin levels positively correlate with insulin resistance despite an inverse association with total adiposity in lean and severely obese patients |
| url | http://europepmc.org/articles/PMC5130198?pdf=render |
| work_keys_str_mv | AT sylvainmayeur plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients AT alainveilleux plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients AT yvespouliot plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients AT benoitlamarche plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients AT jeanfrancoisbeaulieu plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients AT fredericshould plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients AT denisrichard plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients AT andretchernof plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients AT emilelevy plasmalactoferrinlevelspositivelycorrelatewithinsulinresistancedespiteaninverseassociationwithtotaladiposityinleanandseverelyobesepatients |