Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias
Abstract Stage II cholinergic retinal waves are one of the first instances of neural activity in the visual system as they are present at a developmental timepoint in which light-evoked activity remains largely undetectable. These waves of spontaneous neural activity sweeping across the developing r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29572-2 |
| _version_ | 1797864771073081344 |
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| author | Matthew J. Tarchick Dustin A. Clute Jordan M. Renna |
| author_facet | Matthew J. Tarchick Dustin A. Clute Jordan M. Renna |
| author_sort | Matthew J. Tarchick |
| collection | DOAJ |
| description | Abstract Stage II cholinergic retinal waves are one of the first instances of neural activity in the visual system as they are present at a developmental timepoint in which light-evoked activity remains largely undetectable. These waves of spontaneous neural activity sweeping across the developing retina are generated by starburst amacrine cells, depolarize retinal ganglion cells, and drive the refinement of retinofugal projections to numerous visual centers in the brain. Building from several well-established models, we assemble a spatial computational model of starburst amacrine cell-mediated wave generation and wave propagation that includes three significant advancements. First, we model the intrinsic spontaneous bursting of the starburst amacrine cells, including the slow afterhyperpolarization, which shapes the stochastic process of wave generation. Second, we establish a mechanism of wave propagation using reciprocal acetylcholine release, synchronizing the bursting activity of neighboring starburst amacrine cells. Third, we model the additional starburst amacrine cell release of GABA, changing the spatial propagation of retinal waves and in certain instances, the directional bias of the retinal wave front. In total, these advancements comprise a now more comprehensive model of wave generation, propagation, and direction bias. |
| first_indexed | 2024-04-09T22:57:35Z |
| format | Article |
| id | doaj.art-b32106aaeacc4f919fb92a7d531327b6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:57:35Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b32106aaeacc4f919fb92a7d531327b62023-03-22T11:09:46ZengNature PortfolioScientific Reports2045-23222023-02-0113111610.1038/s41598-023-29572-2Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction biasMatthew J. Tarchick0Dustin A. Clute1Jordan M. Renna2Department of Biology, University of AkronDepartment of Biology, University of AkronDepartment of Biology, University of AkronAbstract Stage II cholinergic retinal waves are one of the first instances of neural activity in the visual system as they are present at a developmental timepoint in which light-evoked activity remains largely undetectable. These waves of spontaneous neural activity sweeping across the developing retina are generated by starburst amacrine cells, depolarize retinal ganglion cells, and drive the refinement of retinofugal projections to numerous visual centers in the brain. Building from several well-established models, we assemble a spatial computational model of starburst amacrine cell-mediated wave generation and wave propagation that includes three significant advancements. First, we model the intrinsic spontaneous bursting of the starburst amacrine cells, including the slow afterhyperpolarization, which shapes the stochastic process of wave generation. Second, we establish a mechanism of wave propagation using reciprocal acetylcholine release, synchronizing the bursting activity of neighboring starburst amacrine cells. Third, we model the additional starburst amacrine cell release of GABA, changing the spatial propagation of retinal waves and in certain instances, the directional bias of the retinal wave front. In total, these advancements comprise a now more comprehensive model of wave generation, propagation, and direction bias.https://doi.org/10.1038/s41598-023-29572-2 |
| spellingShingle | Matthew J. Tarchick Dustin A. Clute Jordan M. Renna Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias Scientific Reports |
| title | Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias |
| title_full | Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias |
| title_fullStr | Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias |
| title_full_unstemmed | Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias |
| title_short | Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias |
| title_sort | modeling cholinergic retinal waves starburst amacrine cells shape wave generation propagation and direction bias |
| url | https://doi.org/10.1038/s41598-023-29572-2 |
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