γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy
Traditional magnetothermal nanoparticles showed great limitations for the diagnosis of tumor location in a dynamic physiological environment in vivo. Here, we show an one-step photo-click method based on the composite structure of γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres to meet this...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522006840 |
| _version_ | 1818028745990078464 |
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| author | Yanfang Zhou Piaoyi Chen Mianrong Chen Jiesong Li Xufeng Li Lingyin Lin Yingying Lun Qiuxia Li Qinglin Xiao Yugang Huang Xianshu Wang Hongzhi Zou Guodong Ye |
| author_facet | Yanfang Zhou Piaoyi Chen Mianrong Chen Jiesong Li Xufeng Li Lingyin Lin Yingying Lun Qiuxia Li Qinglin Xiao Yugang Huang Xianshu Wang Hongzhi Zou Guodong Ye |
| author_sort | Yanfang Zhou |
| collection | DOAJ |
| description | Traditional magnetothermal nanoparticles showed great limitations for the diagnosis of tumor location in a dynamic physiological environment in vivo. Here, we show an one-step photo-click method based on the composite structure of γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres to meet this challenge. The advantages are to prepare the magnetic microspheres not in extreme conditions and using sucrose as the polymeric matrix to prevent Fe2O3 nanoparticles from agglomeration. A series of in vitro and in vivo experiments showed that γ-Fe2O3@PSAE has excellent stability in biological medium and inappreciable cytotoxicity. Moreover obvious tumor magnetic resonance imaging contrasts were observed based on response of γ-Fe2O3@PSAE. Under an alternating magnetic field, the heat generated by the magnetic microspheres γ-Fe2O3@PSAE thermally ablated H22 hepatoma cells from Kunming male mice, thereby inhibiting tumors. The histopathological studies showed that the tumor growth was significantly inhibited with the increase in the dosage of γ-Fe2O3@PSAE. |
| first_indexed | 2024-12-10T05:08:41Z |
| format | Article |
| id | doaj.art-b321788cf0d24e448361a6047109bed8 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-10T05:08:41Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-b321788cf0d24e448361a6047109bed82022-12-22T02:01:09ZengElsevierMaterials & Design0264-12752022-10-01222111062γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapyYanfang Zhou0Piaoyi Chen1Mianrong Chen2Jiesong Li3Xufeng Li4Lingyin Lin5Yingying Lun6Qiuxia Li7Qinglin Xiao8Yugang Huang9Xianshu Wang10Hongzhi Zou11Guodong Ye12The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, PR China; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR China; Creative Biosciences (Guangzhou) Co., Ltd., Guangzhou, Guangdong, PR ChinaThe Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, PR China; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR ChinaThe Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, PR ChinaKey Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR ChinaThe Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, PR ChinaKey Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR ChinaKey Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR ChinaKey Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR ChinaKey Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR ChinaKey Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR ChinaCreative Biosciences (Guangzhou) Co., Ltd., Guangzhou, Guangdong, PR ChinaCreative Biosciences (Guangzhou) Co., Ltd., Guangzhou, Guangdong, PR ChinaThe Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, PR China; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, PR China; Corresponding author at: The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, PR China.Traditional magnetothermal nanoparticles showed great limitations for the diagnosis of tumor location in a dynamic physiological environment in vivo. Here, we show an one-step photo-click method based on the composite structure of γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres to meet this challenge. The advantages are to prepare the magnetic microspheres not in extreme conditions and using sucrose as the polymeric matrix to prevent Fe2O3 nanoparticles from agglomeration. A series of in vitro and in vivo experiments showed that γ-Fe2O3@PSAE has excellent stability in biological medium and inappreciable cytotoxicity. Moreover obvious tumor magnetic resonance imaging contrasts were observed based on response of γ-Fe2O3@PSAE. Under an alternating magnetic field, the heat generated by the magnetic microspheres γ-Fe2O3@PSAE thermally ablated H22 hepatoma cells from Kunming male mice, thereby inhibiting tumors. The histopathological studies showed that the tumor growth was significantly inhibited with the increase in the dosage of γ-Fe2O3@PSAE.http://www.sciencedirect.com/science/article/pii/S0264127522006840Sucrose allyl etherMagnetic microsphereMagnetic resonance imagingMagnetothermal therapy |
| spellingShingle | Yanfang Zhou Piaoyi Chen Mianrong Chen Jiesong Li Xufeng Li Lingyin Lin Yingying Lun Qiuxia Li Qinglin Xiao Yugang Huang Xianshu Wang Hongzhi Zou Guodong Ye γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy Materials & Design Sucrose allyl ether Magnetic microsphere Magnetic resonance imaging Magnetothermal therapy |
| title | γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy |
| title_full | γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy |
| title_fullStr | γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy |
| title_full_unstemmed | γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy |
| title_short | γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy |
| title_sort | γ fe2o3 poly sucrose allyl ether magnetic microspheres for tumor enhanced magnetic resonance imaging and high efficiency cooperative magnetothermal therapy |
| topic | Sucrose allyl ether Magnetic microsphere Magnetic resonance imaging Magnetothermal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522006840 |
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