A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway

A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway

A global, quantitative proteomics/systems-biology analysis of the selective pharmacological inhibition of phosphodiesterase-4D (PDE4D) revealed the differential regulation of pathways associated with neuroplasticity in memory-associated brain regions. Subtype selective inhibitors of PDE4D bind in an...

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Bibliographic Details
Main Authors:	Yulu Wang, Shichao Gao, Victor Zheng, Ling Chen, Min Ma, Shichen Shen, Jun Qu, Hanting Zhang, Mark E. Gurney, James M. O’Donnell, Ying Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-12-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	PDE4D BPN14770 memory humanized PDE4D mice cAMP/SIRT1/Akt/Bcl-2 pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2020.599389/full

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