De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcome
B-cell prolymphocytic leukemia (B-PLL) comprises 1% of chronic lymphocytic leukemias. CD5 positivity is seen in 1/3rd of cases which generally arise from pre existing CLL. They have longer median survival compared with de novo B-PLL which are commonly CD5 negative and are more aggressive with an old...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2008-09-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-54154 |
| _version_ | 1797921030448087040 |
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| author | Seema Tyagi Rajat Kumar Rakhee Kar |
| author_facet | Seema Tyagi Rajat Kumar Rakhee Kar |
| author_sort | Seema Tyagi |
| collection | DOAJ |
| description | B-cell prolymphocytic leukemia (B-PLL) comprises 1% of chronic lymphocytic leukemias. CD5 positivity is seen in 1/3rd of cases which generally arise from pre existing CLL. They have longer median survival compared with de novo B-PLL which are commonly CD5 negative and are more aggressive with an older age of presentation. Herewith, we describe a 48-year-old male of de-novo CD5+ B-PLL presenting with minimal lymphadenopathy and massive splenomegaly with 90% atypical lymphoid cells in the peripheral smear and bone marrow. Immunophenotyping was strongly positive for CD5, CD45, CD19, CD22, FMC-7, S-Ig and CD38, moderately positive for CD 11c, weakly positive for CD23 and negative for CD-103 and ZAP 70. The patient responded well to fludarabine and cyclophosphamide and had an uneventful hospital course. Our case illustrates a de-novo B-PLL with aberrant CD5 positivity who had a short duration of illness, younger age at presentation and favourable treatment outcome. |
| first_indexed | 2024-04-10T14:10:13Z |
| format | Article |
| id | doaj.art-b322e731479043b5b1d5a94960ff5ee3 |
| institution | Directory Open Access Journal |
| issn | 1300-7777 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T14:10:13Z |
| publishDate | 2008-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-b322e731479043b5b1d5a94960ff5ee32023-02-15T16:09:48ZengGalenos Publishing HouseTurkish Journal of Hematology1300-77771308-52632008-09-012503149151De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcomeSeema TyagiRajat KumarRakhee KarB-cell prolymphocytic leukemia (B-PLL) comprises 1% of chronic lymphocytic leukemias. CD5 positivity is seen in 1/3rd of cases which generally arise from pre existing CLL. They have longer median survival compared with de novo B-PLL which are commonly CD5 negative and are more aggressive with an older age of presentation. Herewith, we describe a 48-year-old male of de-novo CD5+ B-PLL presenting with minimal lymphadenopathy and massive splenomegaly with 90% atypical lymphoid cells in the peripheral smear and bone marrow. Immunophenotyping was strongly positive for CD5, CD45, CD19, CD22, FMC-7, S-Ig and CD38, moderately positive for CD 11c, weakly positive for CD23 and negative for CD-103 and ZAP 70. The patient responded well to fludarabine and cyclophosphamide and had an uneventful hospital course. Our case illustrates a de-novo B-PLL with aberrant CD5 positivity who had a short duration of illness, younger age at presentation and favourable treatment outcome.http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-54154CD5+prolymphocytic leukemiasplenomegalyprognosis. |
| spellingShingle | Seema Tyagi Rajat Kumar Rakhee Kar De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcome Turkish Journal of Hematology CD5+ prolymphocytic leukemia splenomegaly prognosis. |
| title | De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcome |
| title_full | De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcome |
| title_fullStr | De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcome |
| title_full_unstemmed | De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcome |
| title_short | De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcome |
| title_sort | de novo cd5 b prolymphocytic leukemia pll presenting at younger age with favourable outcome |
| topic | CD5+ prolymphocytic leukemia splenomegaly prognosis. |
| url | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-54154 |
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