How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients
Percutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients. The three randomized controlled trials that led to the widespread adoption of PFO closure excluded patients over the age of 60 years. Older patients frequently have...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2021-10-01
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| Series: | US Cardiology Review |
| Online Access: | https://www.uscjournal.com/articleindex/usc.2020.40 |
| _version_ | 1797200069015896064 |
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| author | Carlos Vazquez-Sosa Stacey D Clegg James C Blankenship |
| author_facet | Carlos Vazquez-Sosa Stacey D Clegg James C Blankenship |
| author_sort | Carlos Vazquez-Sosa |
| collection | DOAJ |
| description | Percutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients. The three randomized controlled trials that led to the widespread adoption of PFO closure excluded patients over the age of 60 years. Older patients frequently have other cardiac and vascular conditions that are common risk factors for stroke, whereas paradoxical embolism through a PFO is relatively rare. Younger patients theoretically benefit the most from closure due to longer lifetime exposure risk and absence of other traditional risk factors. PFO in older patients with cryptogenic strokes is often encountered in clinical practice, making up an increasing number of cardiology referrals, yet cardiologists lack guidelines and evaluation tools for these patients. This review explores the history of PFO closure – emphasizing data in older adults – and discusses the evaluation and treatment of older people with cryptogenic stroke and PFO while further trials in this important population are awaited. |
| first_indexed | 2024-03-07T17:41:16Z |
| format | Article |
| id | doaj.art-b323103fa1b54065adbaba5e98ebeea0 |
| institution | Directory Open Access Journal |
| issn | 1758-3896 1758-390X |
| language | English |
| last_indexed | 2024-04-24T07:25:47Z |
| publishDate | 2021-10-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | US Cardiology Review |
| spelling | doaj.art-b323103fa1b54065adbaba5e98ebeea02024-04-20T16:02:25ZengRadcliffe Medical MediaUS Cardiology Review1758-38961758-390X2021-10-011510.15420/usc.2020.40How Old is Too Old? Closure of Patent Foramen Ovale in Older PatientsCarlos Vazquez-Sosa0Stacey D Clegg1James C Blankenship2University of New Mexico Health Science Center, Albuquerque, NMUniversity of New Mexico Health Science Center, Albuquerque, NM; New Mexico Veterans Administration Medical Center, Albuquerque, NMUniversity of New Mexico Health Science Center, Albuquerque, NMPercutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients. The three randomized controlled trials that led to the widespread adoption of PFO closure excluded patients over the age of 60 years. Older patients frequently have other cardiac and vascular conditions that are common risk factors for stroke, whereas paradoxical embolism through a PFO is relatively rare. Younger patients theoretically benefit the most from closure due to longer lifetime exposure risk and absence of other traditional risk factors. PFO in older patients with cryptogenic strokes is often encountered in clinical practice, making up an increasing number of cardiology referrals, yet cardiologists lack guidelines and evaluation tools for these patients. This review explores the history of PFO closure – emphasizing data in older adults – and discusses the evaluation and treatment of older people with cryptogenic stroke and PFO while further trials in this important population are awaited.https://www.uscjournal.com/articleindex/usc.2020.40 |
| spellingShingle | Carlos Vazquez-Sosa Stacey D Clegg James C Blankenship How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients US Cardiology Review |
| title | How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients |
| title_full | How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients |
| title_fullStr | How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients |
| title_full_unstemmed | How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients |
| title_short | How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients |
| title_sort | how old is too old closure of patent foramen ovale in older patients |
| url | https://www.uscjournal.com/articleindex/usc.2020.40 |
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