Cardiac biomarkers in acute coronary syndromes
Cardiac biomarkers play a significant role in the diagnosis, risk assessment, and management of patients with acute coronary syndromes (ACS). Several biomarkers identify different components of the pathophysiology of ACS: troponins are markers of myocyte necrosis, natriuretic peptides reflect neuroh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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South African Heart Association
2017-04-01
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| Series: | SA Heart Journal |
| Subjects: | |
| Online Access: | https://www.journals.ac.za/index.php/SAHJ/article/view/2048 |
| _version_ | 1818935429345312768 |
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| author | Naresh Ranjith Datshana P. Naidoo |
| author_facet | Naresh Ranjith Datshana P. Naidoo |
| author_sort | Naresh Ranjith |
| collection | DOAJ |
| description | Cardiac biomarkers play a significant role in the diagnosis, risk assessment, and management of patients with acute coronary syndromes (ACS). Several biomarkers identify different components of the pathophysiology of ACS: troponins are markers of myocyte necrosis, natriuretic peptides reflect neurohormonal activation and myocardial dysfunction, and C-reactive protein reflects various inflammatory processes. Whilst there are a number of established and novel biomarkers to assess ischemia, necrosis and myocardial dysfunction in coronary artery disease, it is probable that no single biomarker will emerge that provides appropriate information for all clinical settings of ACS. This suggests that ongoing efforts in plasma-based biomarker research should concentrate on the use of a multimarker approach to enhance our diagnosis, prognostic assessment, and management of patients with suspected ACS, as compared with using individual markers alone. It is recommended that current practice involve the selective use of biomarkers in patients in whom a more complete assessment of risk is desired. At present, routine biomarker measurement is not advocated until further data become available, which will support the benefit of specific therapeutic interventions. |
| first_indexed | 2024-12-20T05:20:02Z |
| format | Article |
| id | doaj.art-b3254ff1aa184ce580787d0ffa09f56d |
| institution | Directory Open Access Journal |
| issn | 2071-4602 1996-6741 |
| language | English |
| last_indexed | 2024-12-20T05:20:02Z |
| publishDate | 2017-04-01 |
| publisher | South African Heart Association |
| record_format | Article |
| series | SA Heart Journal |
| spelling | doaj.art-b3254ff1aa184ce580787d0ffa09f56d2022-12-21T19:52:03ZengSouth African Heart AssociationSA Heart Journal2071-46021996-67412017-04-01527-7510.24170/5-2-2048Cardiac biomarkers in acute coronary syndromesNaresh Ranjith0Datshana P. Naidoo1Inkosi Albert Luthuli Central HospitalInkosi Albert Luthuli Central HospitalCardiac biomarkers play a significant role in the diagnosis, risk assessment, and management of patients with acute coronary syndromes (ACS). Several biomarkers identify different components of the pathophysiology of ACS: troponins are markers of myocyte necrosis, natriuretic peptides reflect neurohormonal activation and myocardial dysfunction, and C-reactive protein reflects various inflammatory processes. Whilst there are a number of established and novel biomarkers to assess ischemia, necrosis and myocardial dysfunction in coronary artery disease, it is probable that no single biomarker will emerge that provides appropriate information for all clinical settings of ACS. This suggests that ongoing efforts in plasma-based biomarker research should concentrate on the use of a multimarker approach to enhance our diagnosis, prognostic assessment, and management of patients with suspected ACS, as compared with using individual markers alone. It is recommended that current practice involve the selective use of biomarkers in patients in whom a more complete assessment of risk is desired. At present, routine biomarker measurement is not advocated until further data become available, which will support the benefit of specific therapeutic interventions.https://www.journals.ac.za/index.php/SAHJ/article/view/2048acute coronary syndromes (acs)cardiac biomarkersacute myocardial infarction |
| spellingShingle | Naresh Ranjith Datshana P. Naidoo Cardiac biomarkers in acute coronary syndromes SA Heart Journal acute coronary syndromes (acs) cardiac biomarkers acute myocardial infarction |
| title | Cardiac biomarkers in acute coronary syndromes |
| title_full | Cardiac biomarkers in acute coronary syndromes |
| title_fullStr | Cardiac biomarkers in acute coronary syndromes |
| title_full_unstemmed | Cardiac biomarkers in acute coronary syndromes |
| title_short | Cardiac biomarkers in acute coronary syndromes |
| title_sort | cardiac biomarkers in acute coronary syndromes |
| topic | acute coronary syndromes (acs) cardiac biomarkers acute myocardial infarction |
| url | https://www.journals.ac.za/index.php/SAHJ/article/view/2048 |
| work_keys_str_mv | AT nareshranjith cardiacbiomarkersinacutecoronarysyndromes AT datshanapnaidoo cardiacbiomarkersinacutecoronarysyndromes |