EFEMP1 binds to STEAP1 to promote osteosarcoma proliferation and invasion via the Wnt/β-catenin and TGF-β/Smad2/3 signal pathways

EFEMP1 binds to STEAP1 to promote osteosarcoma proliferation and invasion via the Wnt/β-catenin and TGF-β/Smad2/3 signal pathways

Purpose: To investigate the prognostic value and function of six-transmembrane epithelial antigen of prostate 1 (STEAP1) in osteosarcoma and determine whether EFEMP1 mediates its effects. Methods: IHC (immunohistochemistry)/ICC (immunocytochemistry) in conjunction with RT-qPCR (quantitative real-tim...

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Bibliographic Details
Main Authors: Dong Zhang, Shasha Han, Xin Pan, Hao Li, Hua Zhao, Xianlei Gao, Songgang Wang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Bone Oncology
Subjects:
STEAP1
Osteosarcoma
Wnt/β-catenin signal pathway
TGF-β/Smad2/3 axis
EMT
Invasion
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137422000483

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http://www.sciencedirect.com/science/article/pii/S2212137422000483

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