Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya.
Arboviruses are among the most important emerging pathogens due to their increasing public health impact. In Kenya, continued population growth and associated urbanization are conducive to vector spread in both urban and rural environments, yet mechanisms of viral amplification in vector populations...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-06-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0008362 |
| _version_ | 1818835306846093312 |
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| author | Claire J Heath Elysse N Grossi-Soyster Bryson A Ndenga Francis M Mutuku Malaya K Sahoo Harun N Ngugi Joel O Mbakaya Peter Siema Uriel Kitron Nayer Zahiri Jimmy Hortion Jesse J Waggoner Charles H King Benjamin A Pinsky A Desiree LaBeaud |
| author_facet | Claire J Heath Elysse N Grossi-Soyster Bryson A Ndenga Francis M Mutuku Malaya K Sahoo Harun N Ngugi Joel O Mbakaya Peter Siema Uriel Kitron Nayer Zahiri Jimmy Hortion Jesse J Waggoner Charles H King Benjamin A Pinsky A Desiree LaBeaud |
| author_sort | Claire J Heath |
| collection | DOAJ |
| description | Arboviruses are among the most important emerging pathogens due to their increasing public health impact. In Kenya, continued population growth and associated urbanization are conducive to vector spread in both urban and rural environments, yet mechanisms of viral amplification in vector populations is often overlooked when assessing risks for outbreaks. Thus, the characterization of local arbovirus circulation in mosquito populations is imperative to better inform risk assessments and vector control practices. Aedes species mosquitoes were captured at varying stages of their life cycle during different seasons between January 2014 and May 2016 at four distinct sites in Kenya, and tested for chikungunya (CHIKV), dengue (DENV) and Zika (ZIKV) viruses by RT-PCR. CHIKV was detected in 45 (5.9%) and DENV in 3 (0.4%) mosquito pools. No ZIKV was detected. Significant regional variation in prevalence was observed, with greater frequency of CHIKV on the coast. DENV was detected exclusively on the coast. Both viruses were detected in immature mosquitoes of both sexes, providing evidence of transovarial transmission of these arboviruses in local mosquitoes. This phenomenon may be driving underlying viral maintenance that may largely contribute to periodic re-emergence among humans in Kenya. |
| first_indexed | 2024-12-19T02:48:37Z |
| format | Article |
| id | doaj.art-b3266bf482014fd8860b562026735425 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-19T02:48:37Z |
| publishDate | 2020-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-b3266bf482014fd8860b5620267354252022-12-21T20:38:46ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352020-06-01146e000836210.1371/journal.pntd.0008362Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya.Claire J HeathElysse N Grossi-SoysterBryson A NdengaFrancis M MutukuMalaya K SahooHarun N NgugiJoel O MbakayaPeter SiemaUriel KitronNayer ZahiriJimmy HortionJesse J WaggonerCharles H KingBenjamin A PinskyA Desiree LaBeaudArboviruses are among the most important emerging pathogens due to their increasing public health impact. In Kenya, continued population growth and associated urbanization are conducive to vector spread in both urban and rural environments, yet mechanisms of viral amplification in vector populations is often overlooked when assessing risks for outbreaks. Thus, the characterization of local arbovirus circulation in mosquito populations is imperative to better inform risk assessments and vector control practices. Aedes species mosquitoes were captured at varying stages of their life cycle during different seasons between January 2014 and May 2016 at four distinct sites in Kenya, and tested for chikungunya (CHIKV), dengue (DENV) and Zika (ZIKV) viruses by RT-PCR. CHIKV was detected in 45 (5.9%) and DENV in 3 (0.4%) mosquito pools. No ZIKV was detected. Significant regional variation in prevalence was observed, with greater frequency of CHIKV on the coast. DENV was detected exclusively on the coast. Both viruses were detected in immature mosquitoes of both sexes, providing evidence of transovarial transmission of these arboviruses in local mosquitoes. This phenomenon may be driving underlying viral maintenance that may largely contribute to periodic re-emergence among humans in Kenya.https://doi.org/10.1371/journal.pntd.0008362 |
| spellingShingle | Claire J Heath Elysse N Grossi-Soyster Bryson A Ndenga Francis M Mutuku Malaya K Sahoo Harun N Ngugi Joel O Mbakaya Peter Siema Uriel Kitron Nayer Zahiri Jimmy Hortion Jesse J Waggoner Charles H King Benjamin A Pinsky A Desiree LaBeaud Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. PLoS Neglected Tropical Diseases |
| title | Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
| title_full | Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
| title_fullStr | Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
| title_full_unstemmed | Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
| title_short | Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. |
| title_sort | evidence of transovarial transmission of chikungunya and dengue viruses in field caught mosquitoes in kenya |
| url | https://doi.org/10.1371/journal.pntd.0008362 |
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