Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures
PurposeThis study compared the efficacy and tolerability of intravenous (i.v.) phenobarbital (PHB) and i.v. levetiracetam (LEV) in children with status epilepticus (SE) or acute repetitive seizure (ARS).MethodsThe medical records of children (age range, 1 month to 15 years) treated with i.v. PHB or...
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2016-01-01
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| Series: | Korean Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://kjp.or.kr/upload/pdf/kjped-59-35.pdf |
| _version_ | 1819055358084120576 |
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| author | Yun-Jeong Lee Mi-Sun Yum Eun-Hee Kim Tae-Sung Ko |
| author_facet | Yun-Jeong Lee Mi-Sun Yum Eun-Hee Kim Tae-Sung Ko |
| author_sort | Yun-Jeong Lee |
| collection | DOAJ |
| description | PurposeThis study compared the efficacy and tolerability of intravenous (i.v.) phenobarbital (PHB) and i.v. levetiracetam (LEV) in children with status epilepticus (SE) or acute repetitive seizure (ARS).MethodsThe medical records of children (age range, 1 month to 15 years) treated with i.v. PHB or LEV for SE or ARS at our single tertiary center were retrospectively reviewed. Seizure termination was defined as seizure cessation within 30 minutes of infusion completion and no recurrence within 24 hours. Information on the demographic variables, electroencephalography and magnetic resonance imaging findings, previous antiepileptic medications, and adverse events after drug infusion was obtained.ResultsThe records of 88 patients with SE or ARS (median age, 18 months; 50 treated with PHB and 38 with LEV) were reviewed. The median initial dose of i.v. PHB was 20 mg/kg (range, 10–20 mg/kg) and that of i.v. LEV was 30 mg/kg (range, 20–30 mg/kg). Seizure termination occurred in 57.9% of patients treated with i.v. LEV (22 of 38) and 74.0% treated with i.v. PHB (37 of 50) (P=0.111). The factor associated with seizure termination was the type of event (SE vs. ARS) in each group. Adverse effects were reported in 13.2% of patients treated with i.v. LEV (5 of 38; n=4, aggressive behavior and n=1, vomiting), and 28.0% of patients treated with i.v. PHB (14 of 50).ConclusionIntravenous LEV was efficacious and safe in children with ARS or SE. Further evaluation is needed to determine the most effective and best-tolerated loading dose of i.v. LEV. |
| first_indexed | 2024-12-21T13:06:15Z |
| format | Article |
| id | doaj.art-b3267531bba14e8abac268d45a554cd0 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-21T13:06:15Z |
| publishDate | 2016-01-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-b3267531bba14e8abac268d45a554cd02022-12-21T19:03:01ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582016-01-01591353910.3345/kjp.2016.59.1.3520125550511Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizuresYun-Jeong Lee0Mi-Sun Yum1Eun-Hee Kim2Tae-Sung Ko3Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, Korea.Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, Korea.Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, Korea.Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, Korea.PurposeThis study compared the efficacy and tolerability of intravenous (i.v.) phenobarbital (PHB) and i.v. levetiracetam (LEV) in children with status epilepticus (SE) or acute repetitive seizure (ARS).MethodsThe medical records of children (age range, 1 month to 15 years) treated with i.v. PHB or LEV for SE or ARS at our single tertiary center were retrospectively reviewed. Seizure termination was defined as seizure cessation within 30 minutes of infusion completion and no recurrence within 24 hours. Information on the demographic variables, electroencephalography and magnetic resonance imaging findings, previous antiepileptic medications, and adverse events after drug infusion was obtained.ResultsThe records of 88 patients with SE or ARS (median age, 18 months; 50 treated with PHB and 38 with LEV) were reviewed. The median initial dose of i.v. PHB was 20 mg/kg (range, 10–20 mg/kg) and that of i.v. LEV was 30 mg/kg (range, 20–30 mg/kg). Seizure termination occurred in 57.9% of patients treated with i.v. LEV (22 of 38) and 74.0% treated with i.v. PHB (37 of 50) (P=0.111). The factor associated with seizure termination was the type of event (SE vs. ARS) in each group. Adverse effects were reported in 13.2% of patients treated with i.v. LEV (5 of 38; n=4, aggressive behavior and n=1, vomiting), and 28.0% of patients treated with i.v. PHB (14 of 50).ConclusionIntravenous LEV was efficacious and safe in children with ARS or SE. Further evaluation is needed to determine the most effective and best-tolerated loading dose of i.v. LEV.http://kjp.or.kr/upload/pdf/kjped-59-35.pdfLevetiracetamPhenobarbitalSeizuresChildStatus epilepticus |
| spellingShingle | Yun-Jeong Lee Mi-Sun Yum Eun-Hee Kim Tae-Sung Ko Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures Korean Journal of Pediatrics Levetiracetam Phenobarbital Seizures Child Status epilepticus |
| title | Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures |
| title_full | Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures |
| title_fullStr | Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures |
| title_full_unstemmed | Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures |
| title_short | Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures |
| title_sort | intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures |
| topic | Levetiracetam Phenobarbital Seizures Child Status epilepticus |
| url | http://kjp.or.kr/upload/pdf/kjped-59-35.pdf |
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