Inflammation and atrial fibrillation: A comprehensive review
Abstract Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-08-01
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| Series: | Journal of Arrhythmia |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/joa3.12077 |
| _version_ | 1818340919635607552 |
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| author | Panagiotis Korantzopoulos Konstantinos P. Letsas Gary Tse Nikolaos Fragakis Christos A. Goudis Tong Liu |
| author_facet | Panagiotis Korantzopoulos Konstantinos P. Letsas Gary Tse Nikolaos Fragakis Christos A. Goudis Tong Liu |
| author_sort | Panagiotis Korantzopoulos |
| collection | DOAJ |
| description | Abstract Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of atrial remodeling. The mechanistic links between atrial remodeling and inflammation are complex while diverse underlying diseases and conditions may affect these pathways. Inflammatory markers have also been associated with AF development, recurrence, perpetuation, total AF burden as well as with thromboembolic complications. The development of specific anti‐inflammatory interventions in this setting seems to be challenging and complicated. Several agents with pleiotropic properties, including anti‐inflammatory, have been tested in experimental and clinical settings with variable results. This updated review provides a concise overview of all available data regarding the role of inflammation in AF including the predictive role of inflammatory markers. Also, current knowledge and future directions on anti‐inflammatory strategies are critically discussed. |
| first_indexed | 2024-12-13T15:50:33Z |
| format | Article |
| id | doaj.art-b328b299619f4a58985926608d003b1e |
| institution | Directory Open Access Journal |
| issn | 1880-4276 1883-2148 |
| language | English |
| last_indexed | 2024-12-13T15:50:33Z |
| publishDate | 2018-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-b328b299619f4a58985926608d003b1e2022-12-21T23:39:32ZengWileyJournal of Arrhythmia1880-42761883-21482018-08-0134439440110.1002/joa3.12077Inflammation and atrial fibrillation: A comprehensive reviewPanagiotis Korantzopoulos0Konstantinos P. Letsas1Gary Tse2Nikolaos Fragakis3Christos A. Goudis4Tong Liu5First Department of Cardiology Medical School University of Ioannina Ioannina GreeceSecond Department of Cardiology Laboratory of Cardiac Electrophysiology “Evangelismos” General Hospital of Athens Athens GreeceDepartment of Medicine and Therapeutics Chinese University of Hong Kong Hong Kong ChinaThird Department of Cardiology Hippokration Hospital Medical School Aristotle University of Thessaloniki Thessaloniki GreeceCardiology Department Serres General Hospital Serres GreeceDepartment of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin ChinaAbstract Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of atrial remodeling. The mechanistic links between atrial remodeling and inflammation are complex while diverse underlying diseases and conditions may affect these pathways. Inflammatory markers have also been associated with AF development, recurrence, perpetuation, total AF burden as well as with thromboembolic complications. The development of specific anti‐inflammatory interventions in this setting seems to be challenging and complicated. Several agents with pleiotropic properties, including anti‐inflammatory, have been tested in experimental and clinical settings with variable results. This updated review provides a concise overview of all available data regarding the role of inflammation in AF including the predictive role of inflammatory markers. Also, current knowledge and future directions on anti‐inflammatory strategies are critically discussed.https://doi.org/10.1002/joa3.12077anti‐inflammatory interventionsatrial fibrillationatrial remodelingC‐reactive proteininflammation |
| spellingShingle | Panagiotis Korantzopoulos Konstantinos P. Letsas Gary Tse Nikolaos Fragakis Christos A. Goudis Tong Liu Inflammation and atrial fibrillation: A comprehensive review Journal of Arrhythmia anti‐inflammatory interventions atrial fibrillation atrial remodeling C‐reactive protein inflammation |
| title | Inflammation and atrial fibrillation: A comprehensive review |
| title_full | Inflammation and atrial fibrillation: A comprehensive review |
| title_fullStr | Inflammation and atrial fibrillation: A comprehensive review |
| title_full_unstemmed | Inflammation and atrial fibrillation: A comprehensive review |
| title_short | Inflammation and atrial fibrillation: A comprehensive review |
| title_sort | inflammation and atrial fibrillation a comprehensive review |
| topic | anti‐inflammatory interventions atrial fibrillation atrial remodeling C‐reactive protein inflammation |
| url | https://doi.org/10.1002/joa3.12077 |
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