Effects of PB‐TURSO on the transcriptional and metabolic landscape of sporadic ALS fibroblasts
Abstract Objective ALS is a rapidly progressive, fatal disorder caused by motor neuron degeneration, for which there is a great unmet therapeutic need. AMX0035, a combination of sodium phenylbutyrate (PB) and taurursodiol (TUDCA, TURSO), has shown promising results in early ALS clinical trials, but...
Main Authors: | Jasmine A. Fels, Jalia Dash, Kent Leslie, Giovanni Manfredi, Hibiki Kawamata |
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Format: | Article |
Language: | English |
Published: |
Wiley
2022-10-01
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Series: | Annals of Clinical and Translational Neurology |
Online Access: | https://doi.org/10.1002/acn3.51648 |
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