Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study
BackgroundObservational studies have shown that central obesity is associated with adverse cardiac structure and function. However, causal association between central obesity and left ventricular (LV) structure and function in preserved ejection fraction (EF) population is still uncertain.MethodsGen...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1103011/full |
| _version_ | 1797956901586075648 |
|---|---|
| author | Yue Gao Jiaxin Zeng Fengwei Zou Xinwei Zhang Zhiyong Qian Yao Wang Xiaofeng Hou Jiangang Zou Jiangang Zou |
| author_facet | Yue Gao Jiaxin Zeng Fengwei Zou Xinwei Zhang Zhiyong Qian Yao Wang Xiaofeng Hou Jiangang Zou Jiangang Zou |
| author_sort | Yue Gao |
| collection | DOAJ |
| description | BackgroundObservational studies have shown that central obesity is associated with adverse cardiac structure and function. However, causal association between central obesity and left ventricular (LV) structure and function in preserved ejection fraction (EF) population is still uncertain.MethodsGenome-wide association studies summary data of waist circumference adjusted for body mass index (WCadjBMI) and waist-to-hip ratio adjusted for body mass index (WHRadjBMI) were selected as instrumental variables from the Genetic Investigation of Anthropometric Traits (GIANT) Consortium (n = 224,459). Outcome datasets for LV parameters including LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), LV ejection fraction (LVEF), LV mass (LVM), and LV mass-to-end-diastolic volume ratio (LVMVR) were obtained from the participants without prevalent myocardial infarction or heart failure (LVEF ≥ 50%) in UK Biobank Cardiovascular Magnetic Resonance sub-study (n = 16,923). Two-sample Mendelian randomization (MR) was performed with the inverse-variance weighted (IVW) method as the primary estimate and with the weighted median and MR-Egger as the supplemental estimates. Sensitivity analysis was used to assess the heterogeneity and pleiotropic bias in the MR results.ResultsIn the IVW analysis, every 1-standard deviation (SD) higher WHRadjBMI was significantly associated with higher LVMVR (β = 0.4583; 95% confidence interval [CI]: 0.2921 to 0.6244; P = 6.418 × 10–8) and lower LVEDV (β = –0.2395; 95% CI: –0.3984 to –0.0807; P = 0.0031) after Bonferroni adjustment. No heterogeneity and horizontal pleiotropy were detected in the analysis. No association of WCadjBMI was found with LVEF, LVEDV, LVESV, LVM, or LVMVR.ConclusionOur findings provide evidence of significant causal association between WHRadjBMI and adverse changes in LV structure and function in preserved EF population. |
| first_indexed | 2024-04-10T23:55:57Z |
| format | Article |
| id | doaj.art-b329255057e342eb9698998f3decc2d2 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T23:55:57Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b329255057e342eb9698998f3decc2d22023-01-10T13:30:52ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.11030111103011Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization studyYue Gao0Jiaxin Zeng1Fengwei Zou2Xinwei Zhang3Zhiyong Qian4Yao Wang5Xiaofeng Hou6Jiangang Zou7Jiangang Zou8Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaMontefiore Medical Center, New York, NY, United StatesDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, ChinaBackgroundObservational studies have shown that central obesity is associated with adverse cardiac structure and function. However, causal association between central obesity and left ventricular (LV) structure and function in preserved ejection fraction (EF) population is still uncertain.MethodsGenome-wide association studies summary data of waist circumference adjusted for body mass index (WCadjBMI) and waist-to-hip ratio adjusted for body mass index (WHRadjBMI) were selected as instrumental variables from the Genetic Investigation of Anthropometric Traits (GIANT) Consortium (n = 224,459). Outcome datasets for LV parameters including LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), LV ejection fraction (LVEF), LV mass (LVM), and LV mass-to-end-diastolic volume ratio (LVMVR) were obtained from the participants without prevalent myocardial infarction or heart failure (LVEF ≥ 50%) in UK Biobank Cardiovascular Magnetic Resonance sub-study (n = 16,923). Two-sample Mendelian randomization (MR) was performed with the inverse-variance weighted (IVW) method as the primary estimate and with the weighted median and MR-Egger as the supplemental estimates. Sensitivity analysis was used to assess the heterogeneity and pleiotropic bias in the MR results.ResultsIn the IVW analysis, every 1-standard deviation (SD) higher WHRadjBMI was significantly associated with higher LVMVR (β = 0.4583; 95% confidence interval [CI]: 0.2921 to 0.6244; P = 6.418 × 10–8) and lower LVEDV (β = –0.2395; 95% CI: –0.3984 to –0.0807; P = 0.0031) after Bonferroni adjustment. No heterogeneity and horizontal pleiotropy were detected in the analysis. No association of WCadjBMI was found with LVEF, LVEDV, LVESV, LVM, or LVMVR.ConclusionOur findings provide evidence of significant causal association between WHRadjBMI and adverse changes in LV structure and function in preserved EF population.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1103011/fullcentral obesityleft ventricular structure and functioncausal associationMendelian randomizationwaist-to-hip ratio |
| spellingShingle | Yue Gao Jiaxin Zeng Fengwei Zou Xinwei Zhang Zhiyong Qian Yao Wang Xiaofeng Hou Jiangang Zou Jiangang Zou Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study Frontiers in Cardiovascular Medicine central obesity left ventricular structure and function causal association Mendelian randomization waist-to-hip ratio |
| title | Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study |
| title_full | Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study |
| title_fullStr | Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study |
| title_full_unstemmed | Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study |
| title_short | Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study |
| title_sort | causal effect of central obesity on left ventricular structure and function in preserved ef population a mendelian randomization study |
| topic | central obesity left ventricular structure and function causal association Mendelian randomization waist-to-hip ratio |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1103011/full |
| work_keys_str_mv | AT yuegao causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy AT jiaxinzeng causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy AT fengweizou causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy AT xinweizhang causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy AT zhiyongqian causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy AT yaowang causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy AT xiaofenghou causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy AT jiangangzou causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy AT jiangangzou causaleffectofcentralobesityonleftventricularstructureandfunctioninpreservedefpopulationamendelianrandomizationstudy |