Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?
Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/8/1180 |
| _version_ | 1827684386638659584 |
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| author | Giovanna Rassu Milena Sorrenti Laura Catenacci Barbara Pavan Luca Ferraro Elisabetta Gavini Maria Cristina Bonferoni Paolo Giunchedi Alessandro Dalpiaz |
| author_facet | Giovanna Rassu Milena Sorrenti Laura Catenacci Barbara Pavan Luca Ferraro Elisabetta Gavini Maria Cristina Bonferoni Paolo Giunchedi Alessandro Dalpiaz |
| author_sort | Giovanna Rassu |
| collection | DOAJ |
| description | Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipients, as solubilizers and absorption promoters, and as active ingredients due to their several biological activities (antiviral, antiparasitic, anti-atherosclerotic, and neuroprotective). The use of CDs in nasal formulations allowed obtaining versatile drug delivery systems intended for local and systemic effects, as well as for nose-to-brain transport of drugs. In vitro and in vivo models currently employed are suitable to analyze the effects of CDs in nasal formulations. Therefore, CDs are versatile pharmaceutical materials, and due to the continual synthesis of new CDs derivatives, the research on the new nasal applications is an interesting field evolving in the coming years, to which Italian research will still contribute. |
| first_indexed | 2024-03-10T08:29:31Z |
| format | Article |
| id | doaj.art-b32d72663b884e8dabfce84d31e1a78b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T08:29:31Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b32d72663b884e8dabfce84d31e1a78b2023-11-22T09:13:52ZengMDPI AGPharmaceutics1999-49232021-07-01138118010.3390/pharmaceutics13081180Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?Giovanna Rassu0Milena Sorrenti1Laura Catenacci2Barbara Pavan3Luca Ferraro4Elisabetta Gavini5Maria Cristina Bonferoni6Paolo Giunchedi7Alessandro Dalpiaz8Department of Chemistry and Pharmacy, University of Sassari, Via Muroni 23a, I-07100 Sassari, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, I-27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, I-27100 Pavia, ItalyDepartment of Neuroscience and Rehabilitation—Section of Physiology, University of Ferrara, Via Borsari 46, I-44121 Ferrara, ItalyDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Borsari 46, I-44121 Ferrara, ItalyDepartment of Chemistry and Pharmacy, University of Sassari, Via Muroni 23a, I-07100 Sassari, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, I-27100 Pavia, ItalyDepartment of Chemistry and Pharmacy, University of Sassari, Via Muroni 23a, I-07100 Sassari, ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Fossato di Mortara 19, I-44121 Ferrara, ItalyCyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipients, as solubilizers and absorption promoters, and as active ingredients due to their several biological activities (antiviral, antiparasitic, anti-atherosclerotic, and neuroprotective). The use of CDs in nasal formulations allowed obtaining versatile drug delivery systems intended for local and systemic effects, as well as for nose-to-brain transport of drugs. In vitro and in vivo models currently employed are suitable to analyze the effects of CDs in nasal formulations. Therefore, CDs are versatile pharmaceutical materials, and due to the continual synthesis of new CDs derivatives, the research on the new nasal applications is an interesting field evolving in the coming years, to which Italian research will still contribute.https://www.mdpi.com/1999-4923/13/8/1180cyclodextrinintranasalformulationlocal therapysystemic drug deliverynose-to-brain |
| spellingShingle | Giovanna Rassu Milena Sorrenti Laura Catenacci Barbara Pavan Luca Ferraro Elisabetta Gavini Maria Cristina Bonferoni Paolo Giunchedi Alessandro Dalpiaz Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives? Pharmaceutics cyclodextrin intranasal formulation local therapy systemic drug delivery nose-to-brain |
| title | Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives? |
| title_full | Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives? |
| title_fullStr | Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives? |
| title_full_unstemmed | Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives? |
| title_short | Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives? |
| title_sort | versatile nasal application of cyclodextrins excipients and or actives |
| topic | cyclodextrin intranasal formulation local therapy systemic drug delivery nose-to-brain |
| url | https://www.mdpi.com/1999-4923/13/8/1180 |
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