Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma
Aim. Tostudy the content and profile of short-chain fatty acids (SCFAs) in faeces of patients with bronchial asthma and healthy individuals, as well as to evaluate possible correlations between the SCFA spectrum and clinical phenotype of patients with bronchial asthma. Materials and methods. 44 pati...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2019-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/355 |
| _version_ | 1797245216868007936 |
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| author | O. Yu. Zolnikova N. D. Potskhverashvili N. I. Kokina A. S. Trukhmanov V. T. Ivashkin |
| author_facet | O. Yu. Zolnikova N. D. Potskhverashvili N. I. Kokina A. S. Trukhmanov V. T. Ivashkin |
| author_sort | O. Yu. Zolnikova |
| collection | DOAJ |
| description | Aim. Tostudy the content and profile of short-chain fatty acids (SCFAs) in faeces of patients with bronchial asthma and healthy individuals, as well as to evaluate possible correlations between the SCFA spectrum and clinical phenotype of patients with bronchial asthma. Materials and methods. 44 patients with asthma and 17 healthy volunteers participated in the study. All participants underwent a generally accepted range of clinical and laboratory studies, as well as functional respiratory tests. The SCFA spectrum was determined using gas-liquid chromatographic analysis. The results of patients with asthma showed a significant decrease in the total fatty acid content in faeces (p <0.001); changes in the absolute concentrations of individual acids, such as acetate (p <0.001), propionate (p <0.001) and butyrate (p <0.001); as well as a change in the total isoacid content (p <0.001). In 83% of the cases, the anaerobic type of the SCFA spectrum was detected. The aerobic type of the SCFA metabolic profile was detected in 17% of the cases. The change in the metabolic profile did not depend on the phenotype of the disease.Conclusion. Changes in SCFAs indicate pronounced disorders in the microbiocenosis of the intestinal biotope. The values of the anaerobic index in the context of various changes in the acid metabolic profile indicate the disturbance of the microorganism’s habitat, contributing to the growth of anaerobic or aerobic microflora populations. |
| first_indexed | 2024-03-08T09:21:17Z |
| format | Article |
| id | doaj.art-b32e60857c1149018e7852a00a33b939 |
| institution | Directory Open Access Journal |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| last_indexed | 2024-04-24T19:23:23Z |
| publishDate | 2019-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj.art-b32e60857c1149018e7852a00a33b9392024-03-25T16:53:08ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732019-05-01292535910.22416/1382-4376-2019-29-2-53-59304Intestinal Short-Chain Fatty Acids in Patients with Bronchial AsthmaO. Yu. Zolnikova0N. D. Potskhverashvili1N. I. Kokina2A. S. Trukhmanov3V. T. Ivashkin4I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim. Tostudy the content and profile of short-chain fatty acids (SCFAs) in faeces of patients with bronchial asthma and healthy individuals, as well as to evaluate possible correlations between the SCFA spectrum and clinical phenotype of patients with bronchial asthma. Materials and methods. 44 patients with asthma and 17 healthy volunteers participated in the study. All participants underwent a generally accepted range of clinical and laboratory studies, as well as functional respiratory tests. The SCFA spectrum was determined using gas-liquid chromatographic analysis. The results of patients with asthma showed a significant decrease in the total fatty acid content in faeces (p <0.001); changes in the absolute concentrations of individual acids, such as acetate (p <0.001), propionate (p <0.001) and butyrate (p <0.001); as well as a change in the total isoacid content (p <0.001). In 83% of the cases, the anaerobic type of the SCFA spectrum was detected. The aerobic type of the SCFA metabolic profile was detected in 17% of the cases. The change in the metabolic profile did not depend on the phenotype of the disease.Conclusion. Changes in SCFAs indicate pronounced disorders in the microbiocenosis of the intestinal biotope. The values of the anaerobic index in the context of various changes in the acid metabolic profile indicate the disturbance of the microorganism’s habitat, contributing to the growth of anaerobic or aerobic microflora populations.https://www.gastro-j.ru/jour/article/view/355bronchial asthmashort-chain fatty acidsmicrofloraimmunomodulation |
| spellingShingle | O. Yu. Zolnikova N. D. Potskhverashvili N. I. Kokina A. S. Trukhmanov V. T. Ivashkin Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma Российский журнал гастроэнтерологии, гепатологии, колопроктологии bronchial asthma short-chain fatty acids microflora immunomodulation |
| title | Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma |
| title_full | Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma |
| title_fullStr | Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma |
| title_full_unstemmed | Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma |
| title_short | Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma |
| title_sort | intestinal short chain fatty acids in patients with bronchial asthma |
| topic | bronchial asthma short-chain fatty acids microflora immunomodulation |
| url | https://www.gastro-j.ru/jour/article/view/355 |
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